Results 91 to 100 of about 10,163,458 (288)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The symmetry principle and the concept of time in actor-network theory [PDF]

Соціологія, 2019
The article addresses some problems of interpreting the symmetry principle and the concept of time in actor-network theory (ANT). The relationships between human and non-human actors constitute the basis for one of the key theses in ANT, which is the ...
Mykhailo Akulov
doaj  

Intersectoral Collaboration to Promote Child Development: The Contributions of the Actor-Network Theory. [PDF]

Qual Health Res, 2023
Chiari APG, Senna MIB, Gomes VE, Freire MDSM, Soares ARDS, Alves CRL, Cury GC, Ferreira RC.   +7 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Aerial Digital Archaeology and Data Ethics through the Lens of Actor-Network Theory

Ethics in Progress
Actor-network theory emphasizes the importance of technology in archaeological research, particularly in aerial digital archaeology. It deconstructs objective narratives by revealing the complexity of knowledge production, including the archaeologist’s ...
Sayumphu Ros
doaj   +1 more source

Waste Struggle: Political Ecology Analysis on Urban Waste Conflict in Pekanbaru [PDF]

E3S Web of Conferences
This article analyzes waste management conflict in Pekanbaru through the perspectives of political ecology and Actor-Network Theory (ANT). Based on rapid ethnographic research conducted in West Tangkerang Village, Marpoyan Damai District, the findings ...
El Amady M. Rawa, Yanti Rina Novia
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Review essay: Recovering assemblages: Unfolding sociomaterial relations of drug use and recovery by Aysel Sultan

International Journal of Narrative Therapy and Community Work
Tom Strong reviews Aysel Sultan (2022). Recovering assemblages: Unfolding sociomaterial relations of drug use and recovery. Palgrave Macmillan. 290pp. ISBN 978-981-19-1234-4, ISBN 978-981-19-1235-1 (eBook).
Tom Strong
doaj   +1 more source

Black boxes and information pathways: An actor-network theory approach to breast cancer survivorship care. [PDF]

Soc Sci Med, 2022
Lefkowitz D.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source