Results 71 to 80 of about 10,163,458 (288)
Entrepreneurship and Sustainability IssuesSmart Specialisation Strategies, their planning and implementation are becoming more important in Europe's transition but also bring up several challenges, especially when it comes to complex innovation processes and requirements arising from the call ...
Christopher Meyer
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Athenea Digital, 2011 Este texto es una presentación del monográfico Diásporas y transiciones en la teoría del actor-red. Sus páginas presentan las principales características de esta teoría, una ...
Blanca Callén +5 more
doaj
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Using Actor-Network Theory to Study Health Information Technology Interventions.
Studies in Health Technology and Informatics, 2019 This chapter introduces Actor-Network Theory, a sociotechnical approach to studying health information technology implementation. The chapter is intended as a pragmatic introduction to the field, acknowledging that there are many contested features of an
K. Cresswell
semanticscholar +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Assemblage thinking and actor-network theory: conjunctions, disjunctions, cross-fertilisations
, 2016 This paper shows that assemblage thinking and actor-network theory (ANT) have much more to gain from each other than debate has so far conceded.
Martin Müller, C. Schurr
semanticscholar +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Network Theory| Networks, Societies, Spheres: Reflections of an Actor-network Theorist
International Journal of Communication, 2011 In one way or another, we are all in this room responsible for having given to the notion of network an immense, and some could say, a hegemonic extension.
Bruno Latour
doaj
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source