Results 211 to 220 of about 289,310 (289)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Michel Cieutat, Christophe Damour, Jacques Demange, Christian Viviani. Actors Studio : histoire et esthétique d’une méthode, de Broadway à Hollywood

Miranda: Revue Pluridisciplinaire du Monde Anglophone
Aurélien Gras
doaj   +1 more source

Stigma and quality of life in hospitalized schizophrenia patient-family caregiver dyads in Northern China: an actor-partner interdependence model analysis. [PDF]

Front Psychiatry
Xie K, Yang H, Ge X, Wang Q, Liu Z, Li X, Ma B.   +6 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Factors influencing self-care among older patients with heart failure and spouses in China: a mixed methods study. [PDF]

Front Public Health
Wu X, Zhuang Y, Wang M, Jin J, Ke Y.
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

AcTor, a novel mTOR stimulator, potentiates ixazomib for the treatment of acute myeloid leukemia. [PDF]

Mol Cancer
Pattanayak SP, Darawshi O, Hajihassani O, Winter JM, Weiler N, Ott M, Rothweiler F, Cinatl J, Michaelis M, Lindner DJ, Green TD, Krassovskaia P, Aruleba RT, Fisher-Wellman KH, Mears JA, Wald D, Eriksson LA, Tirosh B.   +17 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Cross-Lagged Dyadic Associations of Food Insecurity and Depressive Symptoms among Couples Living with HIV and Cardiometabolic Disorders in Malawi. [PDF]

Curr Dev Nutr
Kiyingi J, Bidwell JT, Neilands TB, Weiser SD, Butterfield RM, Mulauzi N, Mkandawire J, Conroy AA.   +7 more
europepmc   +1 more source