Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The Campaign: a case study in identity construction through performance [PDF]
, 2009 This article undertakes a detailed case study of The Campaign, a teaching and learning innovation in media and communications that uses an online educational role-play.
Riddle, Matthew
core +3 more sources
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Market devices and structural dependency: The origins and development of ‘dark pools’
Finance and Society, 2019 ‘Dark pools’ are private, electronic share-trading systems in which participants cannot see each other's buy and sell orders. This article shows that the development of these material ‘market devices’ was strongly shaped by the structural dependency of ...
Donald MacKenzie
doaj +1 more source
The role of actor-networks in the diffusion of management accounting innovations: a comparative study of budgetary control, GP method and Activity-Based Costing in France [PDF]
This research is concerned with the diffusion of management accounting innovations viewed as a process of actor-network building and translation. The aim is to better understand the nature of accounting change.
Nicolas Berland +2 more
core
Michael Porter's Cluster Theory as a local and regional development tool – the rise and fall of cluster policy in the UK [PDF]
, 2013 There has been much written on industrial agglomeration, but it is Michael Porter’s cluster theory, above all others, which has come to dominate local and regional economic development policy. His work has been adopted by the OECD, EU, national and local
Swords, Jon
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Place Construction and Urban Social Transformation : An Actor Network Theory Analysis for Creative Kampong Phenomena in Bandung [PDF]
, 2013 How built environment plays role in social transformation?This question is one concern of social-constructivism approach in study of place. Place construction studies focus on space that socially constructed and social that spatially constructed.
Frans Prasetyo
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Toward an analytical and methodological understanding of actor-network theory [PDF]
, 2015 Actor-Network theory (ANT) is well developed within social studies of science and technology. The last two decades have seen an increasing awareness and interest in ANT within the social sciences and it has increasingly been invoked to theorise the role ...
Jackson, Sharon
core +1 more source