Results 71 to 80 of about 11,180 (240)

The symmetry principle and the concept of time in actor-network theory [PDF]

open access: yesСоціологія, 2019
The article addresses some problems of interpreting the symmetry principle and the concept of time in actor-network theory (ANT). The relationships between human and non-human actors constitute the basis for one of the key theses in ANT, which is the ...
Mykhailo Akulov
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Waste Struggle: Political Ecology Analysis on Urban Waste Conflict in Pekanbaru [PDF]

open access: yesE3S Web of Conferences
This article analyzes waste management conflict in Pekanbaru through the perspectives of political ecology and Actor-Network Theory (ANT). Based on rapid ethnographic research conducted in West Tangkerang Village, Marpoyan Damai District, the findings ...
El Amady M. Rawa, Yanti Rina Novia
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Review essay: Recovering assemblages: Unfolding sociomaterial relations of drug use and recovery by Aysel Sultan

open access: yesInternational Journal of Narrative Therapy and Community Work
Tom Strong reviews Aysel Sultan (2022). Recovering assemblages: Unfolding sociomaterial relations of drug use and recovery. Palgrave Macmillan. 290pp. ISBN 978-981-19-1234-4, ISBN 978-981-19-1235-1 (eBook).
Tom Strong
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

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