Results 101 to 110 of about 959,734 (299)
Public policy actors view success differently, and it matters
, 2022 Literature tells us there are many dimensions of public policy success, and different actors in the policy process will likely focus on different dimensions.
Andrews, Matthew
core +2 more sources
Faire la ville suburbaine. Le projet Sénart
Articulo: Journal of Urban Research, 2010 In 1965, plans for building five new cities were implemented in the outskirts of Paris. Among these new cities, Melun-Sénart – the most recent of them – was not allowed to build its centre until 1985.
Emeric Lambert
doaj +1 more source
Actor-Critic Reinforcement Learning with Phased Actor
CoRRPolicy gradient methods in actor-critic reinforcement learning (RL) have become perhaps the most promising approaches to solving continuous optimal control problems. However, the trial-and-error nature of RL and the inherent randomness associated with solution approximations cause variations in the learned optimal values and policies.
Ruofan Wu, Junmin Zhong, Jennie Si
openaire +3 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Intelligence territoriale en Tunisie : sachants et/ou acteurs
Revue Française des Sciences de l’Information et de la Communication, 2018 This work is a sketch of several doctoral studies in Sciences of the information and communication handling the question of the territorial intelligence.
Vincent Meyer +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
, 2017 Politics, Policy, Populism and Online Media: Investigating Possible (Dis)Connections and Actors in Modern Democracies. (reference IF/01451/2014/CP1239/CT0004)COST Action IS1308: Populist Political Communication in Europe's New Media Environment ...
Strömbäck, Jesper +2 more
core +3 more sources