Results 151 to 160 of about 2,042,802 (273)

How do global health research actors conceptualise inclusion in response to decolonisation calls? A scoping review. [PDF]

BMJ Glob Health
Ewuoso C, Chiwarawara K.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Investigating Environmental Features and Network Interdependencies in Network Formation: A Study of Collaborative, Community-Based Watershed Restoration. [PDF]

Environ Manage
Oesterling N.
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Nutritionists and Dietitians as Key Actors in Local Food Systems: A Systems-Based Social Network Analysis. [PDF]

J Hum Nutr Diet
Pickles S, Stefoska-Needham A, Cullerton K, Kent K, Charlton K.   +4 more
europepmc   +1 more source

Frames, scales and actors [PDF]

, 2008
Bouwen, R., Dewulf, A.
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Promoting active outdoor play and healthy dietary behaviours through the co-creation of supporting physical and social environments for and with primary school-aged children living in underserved neighbourhoods in Europe: the protocol of the B-Challenged project. [PDF]

BMJ Open
Altenburg TM, Pawlowski CS, Ahrens W, Brand T, Buck C, Börnhorst C, Dzielska A, Klaufus L, De Miguel-Etayo P, Moreno L, Okulicz-Kozaryn K, Vrijkotte TGM, Wink R, Belmon LS, Chinapaw MJM.   +14 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Characterizing the Evolution of Inter-Actor Networks in the South China Sea Arbitration via Entropy-Driven Graph Representation Learning from Massive Media Event Data. [PDF]

Entropy (Basel)
Ma M, Yu H, Fang P.
europepmc   +1 more source