Results 191 to 200 of about 959,734 (299)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The Social Amplification of Risk Framework Revisited: Report From an Exst Workshop on Opportunities for Conceptual Advancement. [PDF]

Risk Anal
Tuler SP, Bearth A, Fjæran L, Gaspar R, Gould KP, Ram B, Schweizer PJ, Webler T, Goble R.   +8 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Civil society resistance to anti-rights mobilisation.

BMJ
McGovern T, Meng A, O'Rourke M, Athar R.
europepmc   +1 more source

Eleven-Month-Old Infants Preferentially Look at Helpers But Do Not Reliably Evaluate Inconsistent Actors. [PDF]

Open Mind (Camb)
Woo BM, Tsang A, Hamlin JK.
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Unannounced Drills Using Patient Actors to Evaluate Health Care Facility Readiness for Infectious Disease Outbreaks - New Jersey, New York, and U.S. Virgin Islands, January-June 2026. [PDF]

MMWR Morb Mortal Wkly Rep
Kyaw NTT, Foote MMK, Lo Piccolo AJ, Wallach AB, Chen CY, Zabar SR, Wilhite J, Altshuler L, Guttsman J, Kulin J, Burke S, Hillard L, Alves L, Capers T, Hanley K, Gillespie CC, Mukherjee V.   +16 more
europepmc   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Divergent stakeholder perspectives on antimicrobial resistance and One Health in Ghana: a qualitative study. [PDF]

BMC Glob Public Health
Neuerer M, Baxerres C, Seferiadis AA, Arhinful DK, Amponsah A, Aglanu LM, Louis VR, Amuasi JH, Souares A.   +8 more
europepmc   +1 more source