Results 41 to 50 of about 37,741 (290)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
HTS Teologiese Studies/Theological Studies, 2016 Virtuality in Dietrich Bonhoeffers’ Sanctorum Communio: Collective intelligence as a new epistemology of the church? Collective intelligence has been indicated from biological, philosophical, anthropological and technological developments.
Deon du Toit
doaj +1 more source
Acta Universitatis Carolinae Theologica, 2022 Bonaventure’s epistemology is partly based on his Trinitarian theology. This paper investigates the Trinitarian connotations in this epistemology and their broader significance.
Jonathan Bieler
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Counterpart Theory and Actuality [PDF]
Lewis (The Journal of Philosophy, 65(5), 113–126, 1968) attempts to provide an account of modal talk in terms of the resources of counterpart theory, a first-order theory that eschews transworld identity.
Milford, James
core +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Modality and Actuality: Lukács’s Criticism of Hegel in History and Class Consciousness
Open PhilosophyThe present article tries to show the originality of Lukács’s theory of Actuality (Wirklichkeit) by comparing it with the same notion in Hegel’s Logic. It results that Lukács’s interpretation of Marxism and the Russian Revolution depends on a clear and ...
Rametta Gaetano
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Erkenntnis, 2009 It is known that indicative and subjunctive conditionals interact differently with a rigidifying “actually” operator. The paper studies this difference in an abstract setting. It does not assume the framework of possible world semantics, characterizing “actually” instead by the type of logically valid formulas to which it gives rise.
openaire +3 more sources