Results 51 to 60 of about 30,157 (315)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Sovremennye Issledovaniâ Socialʹnyh Problem, 2015 This article analyzes the views of foreign psycho-pedagogical researchers on a problem of the rite of passage as a tool of sewage for hostile aggression and spiritual and creativity actualization at risk adolescents.
Inga Yuryevna Lebedeva
doaj +1 more source
Compatibility of Self-Actualization and Anxiety in Positive Disintegration
, 1980 Dabrowski’s theory of positive disintegration relates that anxiety appears to be the dynamic of self-actualization. A study to assess this hypothesis (Wilkins, Hjelle, & Thompson, 1977) indicated that self-actualization was incompatible with chronic ...
Dodez, Orin
core +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Armenian Folia Anglistika, 2016 The article aims at disclosing the concept God in J. Fowles philosophical essay “The Aristos” as well as defining linguistic means of its actualization.
Heghine Isahakyan
doaj +1 more source
Les interprétations sémantiques des groupes nominaux sans déterminant en ancien-haut-allemand
Corela, 2023 In modern German, singular noun phrases without any actualizer (type [ØN]sg) encode a non-discrete and undefined aim. In old high German, the marking of nominal categories is the object of current development, and the interpretation of a noun phrase ...
Delphine Pasques
doaj +1 more source
Lifelong Learning and Self-Actualization
, 2009 57th International Phenomenology Congress -- JUN 18-22, 2007 -- World Phenomenol Inst, Istanbul, TURKEYWOS: 000272201600004Life is a process for self-actualization of an individual. We know that self-actualization never ends in the phases of life process.
Kiymet Selvi, Selvi, Kıymet
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Fonction de l’article vis-à-vis de l’absence d’article : focalisation plutôt qu’actualisation ?
Corela, 2023 The general function of the determinant is usually described by linguists and grammarians in terms of “actualization”, referring explicitly or implicitly to the passage of a sign from a “potential” to an “effective” status.
Lidia Lebas-Fraczak
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source