Results 101 to 110 of about 476,790 (282)

Infections Complicating Orthotopic Liver Transplantation: A Study Emphasizing Graft-Related Septicemia [PDF]

, 1976
In 93 recipients of 102 orthotopic liver homografts, the incidence of bacteremia or fungemia exceeded 70%. The graft itself was usually an entry site for systemic infection after both immunologic and nonimmunologic parenchymal injury, especially if there
Hansbrough, JF, Hoelscher, M, Porter, KA, Putnam, CW, Schröter, GPJ, Starzl, TE   +5 more
core   +1 more source

Immunopathogenesis of acute on chronic liver failure

American Journal of Transplantation
Acute-on-chronic liver failure is a well-established description of a high-mortality syndrome of chronic liver disease (usually cirrhosis) with organ failure. While the exact definition is under refinement, the accepted understanding of this entity is in patients with chronic liver disease and various organs in failure and where systemic inflammation ...
Artru, Florent, Mcphail, Mark
openaire   +3 more sources

Two sides of one coin: massive hepatic necrosis and progenitor cell-mediated regeneration in acute liver failure

Frontiers in Physiology, 2015
Massive hepatic necrosis is a key event underlying acute liver failure, a serious clinical syndrome with high mortality. Massive hepatic necrosis in acute liver failure has unique pathophysiological characteristics including extremely rapid parenchymal ...
Honglei eWeng, Xiaobo eCai, Xiaodong eYuan, Roman eLiebe, Steven eDooley, Hai eLi, Tai-Ling eWang   +6 more
doaj   +1 more source

Ammonia toxicity: from head to toe? [PDF]

, 2016
Ammonia is diffused and transported across all plasma membranes. This entails that hyperammonemia leads to an increase in ammonia in all organs and tissues.
Dasarathy, Srinivasan, Mookerjee, Rajeshwar P., Ott, Peter, Rackayova, Veronika, Rangroo Thrane, Vinita, Rose, Christopher, Vairappan, Balasubramaniyan   +6 more
core   +1 more source

Artificial liver support systems: what is new over the last decade?

Annals of Intensive Care, 2018
The liver is a complex organ that performs vital functions of synthesis, heat production, detoxification and regulation; its failure carries a highly critical risk.
Juan José García Martínez, Karim Bendjelid   +1 more
doaj   +1 more source

Liver transplantation for acute-on-chronic liver failure

The Lancet Gastroenterology & Hepatology
Acute-on-chronic liver failure (ACLF) occurs in the context of advanced liver disease and is associated with hepatic and extrahepatic organ failure, eventually leading to a major risk of short-term mortality. To date, there are very few effective therapeutic options for ACLF.
Artru, Florent, Trovato, Francesca, Morrison, Maura, Bernal, William, Mcphail, Mark   +4 more
openaire   +4 more sources

Liver transplantation for critically ill patients with acute on chronic liver failure: a prospective national programme of waitlist prioritisationResearch in context

The Lancet Regional Health. Europe
Summary: Background: Acute on Chronic Liver Failure (ACLF) complicates chronic liver disease (CLD) combining rapidly progressive hepatic with extra-hepatic multiple organ failure and high short-term mortality.
William Bernal, Rhiannon Taylor, Ian A. Rowe, Abhishek Chauhan, Matthew J. Armstrong, Michael E.D. Allison, Gwilym Webb, Tasneem Pirani, Joanna Moore, Laura Burke, Steven Masson, David Cressy, Brian J. Hogan, Rachel Westbrook, Rajiv Jalan, Kenneth J. Simpson, John Isaac, Douglas Thorburn   +17 more
doaj   +1 more source

Abnormal liver function tests in acute heart failure: relationship with clinical characteristics and outcome in the PROTECT study [PDF]

, 2016
Aims: Episodes of acute heart failure (AHF) unfavourably affect multiple organs, which may have an adverse impact on the outcomes. We investigated the prevalence and clinical consequences of abnormal liver function tests (LFTs) in AHF patients ...
Akhter, Allen, Ambrosy, Androne, Biegus, Blyth, Deursen, Edwards, Gheorghiade, Givertz, Harjola, Horwich, Klein, Liu, Massie, Metra, Nikolaou, O'Connor, Peacock, Shinagawa, Weatherley   +20 more
core   +1 more source

Incidence and Mortality of Acute‐on‐Chronic Liver Failure Using Two Definitions in Patients with Compensated Cirrhosis

Hepatology, 2019
The term acute‐on‐chronic liver failure (ACLF) is intended to identify patients with chronic liver disease who develop rapid deterioration of liver function and high short‐term mortality after an acute insult.
N. Mahmud, D. Kaplan, T. Taddei, D. Goldberg   +3 more
semanticscholar   +1 more source

The efficacy and safety of methylprednisolone in hepatitis B virus-related acute-on-chronic liver failure: a prospective multi-center clinical trial

BMC Medicine, 2020
Background Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a severe condition with high mortality due to lack of efficient therapy. Until now, the use of methylprednisolone (MP) in HBV-ACLF is still controversial.
Lin Jia, Ran Xue, Yueke Zhu, Juan Zhao, Juan Li, Wei-Ping He, Xiao-Mei Wang, Zhong-Hui Duan, Mei-Xin Ren, Hai-Xia Liu, Hui-Chun Xing, Qing-Hua Meng   +11 more
doaj   +1 more source