Results 81 to 90 of about 476,540 (287)

Comparative role of tenofovir versus entecavir for treating patients with hepatitis B virus-related acute on chronic liver failure

Journal of Family Medicine and Primary Care, 2021
Introduction: The aim of the study was to compare the safety and efficacy of tenofovir versus entecavir for treatment of naive acute on chronic liver failure (ACLF) due to hepatitis B virus (HBV) (ACLF-B).
Sharker M. S. Hossain, Mamun A Mahtab, Dulal C Das, Sheikh M Noor-E-Alam, Ayub A Mamun, Md. Sakirul I Khan, Sheikh M. F. Akbar, Md Zakiur Rahman, Salimur Rahman   +8 more
doaj   +1 more source

Usefulness of regional right ventricular and right atrial strain for prediction of early and late right ventricular failure following a left ventricular assist device implant: A machine learning approach [PDF]

, 2019
Background: Identifying candidates for left ventricular assist device surgery at risk of right ventricular failure remains difficult. The aim was to identify the most accurate predictors of right ventricular failure among clinical, biological, and ...
Agnese V., Bellavia D., Clemenza F., Coronnello C., di Gesaro G., Falletta C., Gorcsan S. J., Iacovoni A., Maalouf J., Novo G., Pasta S., Pilato M., Sciacca S., Senni M., Simon M.   +14 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Incidence and Short‐Term Prognosis of Acute‐On‐Chronic Liver Failure Defined by Japanese Criteria: A Single‐Center Retrospective Cohort Study From Urban Japan

JGH Open
Background and Aim Acute‐on‐chronic liver failure (ACLF) carries high short‐term mortality, but real‐world evidence under the Japanese ACLF criteria remains limited.
Hidehiro Kamezaki, Terunao Iwanaga, Takahiro Maeda, Junichi Senoo, Sadahisa Ogasawara, Shingo Nakamoto, Naoya Kato   +6 more
doaj   +1 more source

Unraveling the Role of Allo-Antibodies and Transplant Injury. [PDF]

, 2016
Alloimmunity driving rejection in the context of solid organ transplantation can be grossly divided into mechanisms predominantly driven by either T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR), though the co-existence of both ...
Matsuda, Yoshiko, Sarwal, Minnie M
core   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Procalcitonin as a Specific Predictor of Clinical Outcomes in Acute-on-Cirrhosis Sepsis: A Retrospective Pilot Analysis

Livers
Background/Aims: Sepsis as an acute cause of liver dysfunction is associated with high mortality. Routine infection/inflammation markers—C-reactive-protein (CRP), procalcitonin (PCT), and leukocyte count (LeuC)—are frequently used for risk stratification
Mohamad Amer Nashtar, Stamatina Georgitsi, Jan Best, Michael Steckstor, Philipp Aurich, Mustafa Özcürümez, Ali Canbay, Antonios Katsounas   +7 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Prognostic value of plasma level of superoxide dismutase in HBV-related acute-on-chronic liver failure

BMC Gastroenterology, 2022
Background Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is the most prevalent type of ACLF in China. The mortality rate of HBV-ACLF has decreased in recent years due to advances in treatment therapies; however, it is still above 50%
Naijuan Yao, Yajuan He, Yuchao Wu, Fei Wang, Zhen Tian   +4 more
doaj   +1 more source

Acute-on-Chronic Liver Failure: Recent Concepts [PDF]

Journal of Clinical and Experimental Hepatology, 2015
A proportion of patients hospitalized for an acute complication of cirrhosis are at high risk of short-term death. The term Acute-on-Chronic Liver Failure (ACLF) is used to characterize these patients. Until recently there was no evidence-based definition of ACLF.
Richard, Moreau, Rajiv, Jalan, Vicente, Arroyo   +2 more
openaire   +2 more sources