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Annals of Hepatology, 2010 Acute liver failure is a rare but often catastrophic illness affecting the liver and multiple organ systems. Patients with acute liver failure require a multidisciplinary approach for adequate management.
Murali Pathikonda, Santiago J. Munoz, MD
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Apollo Medicine, 2021 Acute liver failure is an uncommon disease presenting with abrupt failure of liver synthetic and detoxification functions on account of widespread damage to hepatocytes and is associated with high mortality.
Vikash Prakash
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Predicting outcome on admission and post-admission for acetaminophen-induced acute liver failure using classification and regression tree models. [PDF]
PLoS ONE, 2015 Assessing prognosis for acetaminophen-induced acute liver failure (APAP-ALF) patients often presents significant challenges. King's College (KCC) has been validated on hospital admission, but little has been published on later phases of illness. We aimed
Jaime Lynn Speiser +3 more
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Journal of Pediatric Critical Care, 2019 Out of various etiology involved in liver pathology viral and metabolic causes are important in children. Hypoxic and ischemic liver injury are commonly seen in PICU.
Kundan Mittal +2 more
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JAAPAABSTRACT Acute liver failure, commonly caused by acetaminophen overdose, is associated with numerous systemic complications including cerebral edema, hypotension, acute kidney injury, and infection. Management is primarily supportive, with an emphasis on excellent neurocritical care.
Girish V, Royer A, John S.
europepmc +9 more sources
The Lancet, 2020 Acute liver failure is a rare syndrome and is primarily caused by paracetamol toxicity in developed nations. Survival for patients with acute liver failure has steadily improved over the last few decades from approximately 20% to greater than 60%. This marked improvement in survival has been due to a combination of improvements in medical practice and ...
Sandro, Vento, Francesca, Cainelli
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Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure. [PDF]
PLoS ONE, 2013 Tools to predict death or spontaneous survival are necessary to inform liver transplantation (LTx) decisions in pediatric acute liver failure (PALF), but such tools are not available.
Nabil Azhar +6 more
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Current Opinion in Critical Care, 2011 Acute liver failure (ALF) results in a multitude of serious complications that often lead to multi-organ failure. This brief review focuses on the pathophysiological processes in ALF and how to manage these.The clinical presentation in ALF ranges from slightly altered conscious level with profound coagulopathy to coma with a catastrophic failure of ...
Fin Stolze, Larsen +1 more
+7 more sources
Procalcitonin Identifies Cell Injury, Not Bacterial Infection, in Acute Liver Failure. [PDF]
PLoS ONE, 2015 Because acute liver failure (ALF) patients share many clinical features with severe sepsis and septic shock, identifying bacterial infection clinically in ALF patients is challenging.
Jody A Rule +6 more
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Detection of Ophthalmic Acid in Serum from Acetaminophen-Induced Acute Liver Failure Patients Is More Frequent in Non-Survivors. [PDF]
PLoS ONE, 2015 Acetaminophen (APAP) hepatotoxicity is related to the formation of N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified through conjugation with reduced glutathione (GSH).
Gurnit Kaur +6 more
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