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Pediatric acute liver failure (PALF) has recently become a subject of great interest when multiple clusters of non-A to non-E severe acute hepatitis in otherwise healthy young children with a median age of 2 years were reported around the world [...]
Claudia Mandato, Pietro Vajro
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Acute liver failure (ALF) (sometimes referred to as fulminant hepatic failure) is a clinical syndrome from a variety of causes resulting from rapid loss in hepatocyte function, typically associated with coagulopathy and encephalopathy in a patient without preexisting liver disease or cirrhosis. Cerebral edema is a cardinal feature and may produce uncal
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Background The incidence of acute liver failure from herpes simplex virus is rare. Case presentation A 71-year-old Japanese man was diagnosed with acute liver failure and was transferred to our hospital.
Kento Shionoya +4 more
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Clinical case: acute on chronic liver failure (ACLF)
Acute-on-chronic liver failure (AcLF) is an acute liver disorder manifested as jaundice (serum bilirubin levels ≥5 mg/dL) and coagulopathy (Inr ≥1.5 or prothrombin activity < 40%), complicated by ascites and/or encephalopathy within 4 weeks, that is ...
Kseniya I. Poperezhaeva +2 more
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Acute Hepatitis B with Pancreatitis and Cholecystitis Leading to Acute Liver Failure and Death
Acute liver failure is defined as severe acute liver injury, concurrent with encephalopathy and loss of hepatic synthetic function, in a patient without known pre-existing liver disease.
Andrew R. Albert +2 more
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Acute liver failure in paracetamol overdose: management, transplantation and best practice [PDF]
In the United Kingdom the most common drug taken in overdose is paracetamol, which is recognised as a major cause of acute liver failure. However death rates from acute liver failure have fallen due to the rapid availability and accessibility of the ...
Toplis, Emma, Mortimore, Gerri
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Babesiosis Presenting as Acute Liver Failure
Babesiosis is a zoonotic, tick-borne infection caused by the protozoan Babesia. It is transmitted by the Ixodes ticks which transmit the infection to humans. Babesia microti, Babesia duncani, Babesia divergens, and Babesia venatorum are species that have
Yousef Nassar, Seth Richter
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Sunitinib-Induced Acute Liver Failure
Drug-induced liver injury is an uncommon but life-threatening entity. Sunitinib is a tyrosine kinase inhibitor used for advanced and imatinib-refractory gastrointestinal stromal tumors. It causes transient elevation in liver enzymes.
Anum Aqsa +4 more
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Xenogeneic, extracorporeal liver perfusion in primates improves the ratio of branched-chain amino acids to aromatic amino acids (Fischer's ratio) [PDF]
In fulminant hepatic failure (FHF), the development of hepatic encephalopathy is associated with grossly abnormal concentrations of plasma amino acids (PAA).
Puhl, G. +7 more
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Acute liver failure is a rare but potentially fatal disease. Adult definition of fulminant hepatic failure, which includes the development of hepatic necrosis and encephalopathy within 8 weeks of onset of liver disease does not apply to acute liver failure in children particularly if secondary to autoimmune or metabolic liver disease.
Laura, Blackmore, William, Bernal
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