Results 151 to 160 of about 1,317,136 (395)
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Interleukin 6 induces a liver-specific nuclear protein that binds to the promoter of acute-phase genes. [PDF]
, 1989 Valeria Poli, R. Cortese
openalex +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Messenger RNA activities of four acute phase proteins during inflammation [PDF]
, 1983 Wolfgang Northemann +5 more
openalex +1 more source
Immunoradiometric assay of circulating C-reactive protein: age-related values in the adult general population [PDF]
, 2000 Background: Increased values of C-reactive protein (CRP), the classical acute phase protein, within the range below 5 mg/L, previously considered to be within the reference interval, are strongly associated with increased risk of atherothrombotic events,
Frohlich, M. +5 more
core
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
Acute-phase proteins and serum immunoglobulins in ankylosing spondylitis. [PDF]
, 1983 Marion Laurent, G. S. Panayi
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Fecal acute phase proteins in cats with chronic enteropathies. [PDF]
J Vet Intern Med, 2023 Karra DA +8 more
europepmc +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Induction of the acute-phase protein serum amyloid P in experimental Chagas' disease [PDF]
, 1982 Júlio Scharfstein +2 more
openalex +1 more source