Results 31 to 40 of about 714,663 (382)

The importance of acute-phase proteins as markers in cancers

Studia Medyczne, 2021
Acute-phase proteins (APPs) form a group of heterogeneous proteins whose synthesis takes place in the liver. This involves mediators such as cytokines and constitutes a response to acute inflammations, bacterial infections, tumours, and autoimmune ...
Paulina Zegarska, Urszula Markowska, Małgorzata Płoszaj   +2 more
doaj   +1 more source

Editorial: dose-dependent ZnO particle-induced acute phase response in humans warrants re-evaluation of occupational exposure limits for metal oxides [PDF]

, 2018
Epidemiological studies link inhalation of particles to increased risk of cardiovascular disease. Inhaled particles may induce cardiovascular disease by several different mechanisms including translocation of particles to systemic circulation, activation
Cassee, Flemming R., Vogel, Ulla Birgitte   +1 more
core   +1 more source

Binding of anisotropic curvature-inducing proteins onto membrane tubes [PDF]

Soft Matter 18, 3384-3394 (2022), 2022
Bin/Amphiphysin/Rvs superfamily proteins and other curvature-inducing proteins have anisotropic shapes and anisotropically bend biomembrane. Here, we report how the anisotropic proteins bind the membrane tube and are orientationally ordered using mean-field theory including an orientation-dependent excluded volume.
arxiv   +1 more source

Curvature sensing of curvature-inducing proteins with internal structure [PDF]

Phys. Rev. E 109, 024403 (2024), 2023
Many types of peripheral and transmembrane proteins can sense and generate membrane curvature. Laterally isotropic proteins and crescent proteins with twofold rotational symmetry, such as Bin/Amphiphysin/Rvs superfamily proteins, have been studied theoretically. However, proteins often have an asymmetric structure or a higher rotational symmetry.
arxiv   +1 more source

Renal Amyloidosis Associated With 5 Novel Variants in the Fibrinogen A Alpha Chain Protein

Kidney International Reports, 2017
Fibrinogen A alpha chain amyloidosis is an autosomal dominant disease associated with mutations in the fibrinogen A alpha chain (FGA) gene, and it is the most common cause of hereditary renal amyloidosis in the UK.
Dorota Rowczenio, Maria Stensland, Gustavo A. de Souza, Erik H. Strøm, Janet A. Gilbertson, Graham Taylor, Nigel Rendell, Shane Minogue, Yvonne A. Efebera, Helen J. Lachmann, Ashutosh D. Wechalekar, Philip N. Hawkins, Ketil R. Heimdal, Kristian Selvig, Inger K. Lægreid, Nathalie Demoulin, Selda Aydin, Julian D. Gillmore, Tale N. Wien   +18 more
doaj   +1 more source

Acute phase proteins in sheep and goats – function, reference ranges and assessment methods: An overview [PDF]

Bulgarian Journal of Veterinary Medicine, 2018
Acute phase response (APR) is activated by disorders in systemic homeostasis. The main purpose of APR is to prevent further tissue damage by isolation and destruction of causative agent, removing the toxic products and providing conditions for tissue ...
P. Iliev, T. Mircheva-Georgieva
doaj   +1 more source

Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel

Scientific Reports, 2017
Dissociation of the native transthyretin (TTR) tetramer is widely accepted as the critical step in TTR amyloid fibrillogenesis. It is modelled by exposure of the protein to non-physiological low pH in vitro and is inhibited by small molecule compounds ...
Guglielmo Verona, P. Patrizia Mangione, Sara Raimondi, Sofia Giorgetti, Giulia Faravelli, Riccardo Porcari, Alessandra Corazza, Julian D. Gillmore, Philip N. Hawkins, Mark B. Pepys, Graham W. Taylor, Vittorio Bellotti   +11 more
doaj   +1 more source

Efficacy of bortezomib, cyclophosphamide and dexamethasone in treatment-naïve patients with high-risk cardiac AL amyloidosis (Mayo Clinic stage III)

Haematologica, 2014
Bortezomib is an active agent in AL amyloidosis and responses to this drug in combination with cyclophosphamide and dexamethasone are both rapid and deep.
Arnaud Jaccard, Raymond L. Comenzo, Parameswaran Hari, Philip N. Hawkins, Murielle Roussel, Pierre Morel, Margaret Macro, Jean-Luc Pellegrin, Estibaliz Lazaro, Dania Mohty, Patrick Mercie, Olivier Decaux, Julian Gillmore, David Lavergne, Frank Bridoux, Ashutosh D. Wechalekar, Christopher P. Venner   +16 more
doaj   +1 more source

Optimal combinations of acute phase proteins for detecting infectious disease in pigs [PDF]

, 2011
Peer reviewedPublisher ...
Campbell, Fiona Margaret, Carpintero, Rakel, Eckersall, P. David, Gruys, Erik, Heegaard, Peter M. H., Lampreave, Fermin, Piñeiro, Matilde, Skall Sorensen, Nanna, Stockmarr, Anders, Toussaint, Mathilda J.M.   +9 more
core   +4 more sources

A novel mechano‐enzymatic cleavage mechanism underlies transthyretin amyloidogenesis

EMBO Molecular Medicine, 2015
The mechanisms underlying transthyretin‐related amyloidosis in vivo remain unclear. The abundance of the 49–127 transthyretin fragment in ex vivo deposits suggests that a proteolytic cleavage has a crucial role in destabilizing the tetramer and releasing
Julien Marcoux, P Patrizia Mangione, Riccardo Porcari, Matteo T Degiacomi, Guglielmo Verona, Graham W Taylor, Sofia Giorgetti, Sara Raimondi, Sarah Sanglier‐Cianférani, Justin LP Benesch, Ciro Cecconi, Mohsin M Naqvi, Julian D Gillmore, Philip N Hawkins, Monica Stoppini, Carol V Robinson, Mark B Pepys, Vittorio Bellotti   +17 more
doaj   +1 more source