Results 61 to 70 of about 714,663 (382)

Length, Protein-Protein Interactions, and Complexity [PDF]

, 2004
The evolutionary reason for the increase in gene length from archaea to prokaryotes to eukaryotes observed in large scale genome sequencing efforts has been unclear. We propose here that the increasing complexity of protein-protein interactions has driven the selection of longer proteins, as longer proteins are more able to distinguish among a larger ...
arxiv   +1 more source

Evaluation of C-Reactive Protein and Fibrinogen in Patients with Chronic and Aggressive Periodontitis: A Clinico-Biochemical Study [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: Periodontal disease is characterised by chronic infection and inflammation in periodontal tissues leading to destruction of alveolar bone with subsequent tooth loss.
Swaroop Chandy, Kiran Joseph, Anila Sankaranarayanan, Annie Issac, George Babu, Bobby Wilson, Jumol Joseph   +6 more
doaj   +1 more source

Combined Inflammatory and Metabolic Defects Reflected by Reduced Serum Protein Levels in Patients with Buruli Ulcer Disease [PDF]

, 2014
Buruli ulcer is a skin disease caused by Mycobacterium ulcerans that is spreading in tropical countries, with major public health and economic implications in West Africa.
AA Pahlevan, AG Fraga, Arnaud Fontanet, B Meijer, BH Ji, C Demangel, Caroline Demangel, D Yeboah-Manu, DC Gore, E Coutanceau, E Coutanceau, E Peresi, EJ Park, F van de Goot, Fatoumata Niang, Fred S. Sarfo, FS Sarfo, FS Sarfo, FS Sarfo, FS Sarfo, Gerd Pluschke, H Hong, H Hong, J Guarner, J Trygg, JD Storey, Jordi Landier, K Asiedu, K Huygen, Kabiru Abass, KM George, L Guenin-Mace, L Guenin-Mace, M Wansbrough-Jones, Mark Forson, Mark Wansbrough-Jones, ME Posthauer, Michael Frimpong, PD Johnson, R Phillips, R Phillips, RE Simmonds, Reid Oldenburg, Richard O. Phillips, S Boulkroun, S Etuaful, WA Nienhuis, William Thompson, Y Benjamini   +48 more
core   +6 more sources

D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile

Nature Communications, 2016
Decrease in Apolipoprotein C-III (ApoC-III) yields a cardioprotective lipoprotein profile. Here, Valleix et al.reveal a novel ApoC-III variant conferring low plasma ApoC-III concentration and cardioprotection despite renal insufficiency, and ...
Sophie Valleix, Guglielmo Verona, Noémie Jourde-Chiche, Brigitte Nédelec, P. Patrizia Mangione, Frank Bridoux, Alain Mangé, Ahmet Dogan, Jean-Michel Goujon, Marie Lhomme, Carolane Dauteuille, Michèle Chabert, Riccardo Porcari, Christopher A. Waudby, Annalisa Relini, Philippa J. Talmud, Oleg Kovrov, Gunilla Olivecrona, Monica Stoppini, John Christodoulou, Philip N. Hawkins, Gilles Grateau, Marc Delpech, Anatol Kontush, Julian D. Gillmore, Athina D. Kalopissis, Vittorio Bellotti   +26 more
doaj   +1 more source

Ceruloplasmin: macromolecular assemblies with iron-containing acute phase proteins. [PDF]

PLoS ONE, 2013
Copper-containing ferroxidase ceruloplasmin (Cp) forms binary and ternary complexes with cationic proteins lactoferrin (Lf) and myeloperoxidase (Mpo) during inflammation.
Valeriya R Samygina, Alexey V Sokolov, Gleb Bourenkov, Maxim V Petoukhov, Maria O Pulina, Elena T Zakharova, Vadim B Vasilyev, Hans Bartunik, Dmitri I Svergun   +8 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

ProNet DB: A proteome-wise database for protein surface property representations and RNA-binding profiles [PDF]

arXiv, 2022
The rapid growth in the number of experimental and predicted protein structures and more complicated protein structures challenge users in computational biology for utilizing the structural information and protein surface property representation. Recently, AlphaFold2 released the comprehensive proteome of various species, and protein surface property ...
arxiv  

Analysis of the hippocampal proteome in ME7 prion disease reveals a predominant astrocytic signature and highlights the brain-restricted production of clusterin in chronic neurodegeneration

, 2013
Prion diseases are characterized by accumulation of misfolded protein, gliosis, synaptic dysfunction, and ultimately neuronal loss. This sequence, mirroring key features of Alzheimer disease, is modeled well in ME7 prion disease.
Asuni, Ayodeji A, Bailey, Joanne, Gray, Bryony, O'Connor, Vincent, Perry, V Hugh, Skipp, Paul   +5 more
core   +1 more source

Acute-phase proteins in osteoarthritis

Seminars in Arthritis and Rheumatism, 1995
The joint destruction of osteoarthritis (OA) comprises loss of articular cartilage resulting from an imbalance of enzyme-catalized cartilage breakdown and regeneration. OA is thought to derive from defective chondrocyte metabolism and thus to inherently lack the large-scale systemic response that is the hallmark of rheumatoid arthritis (RA). Because of
openaire   +3 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source