Results 211 to 220 of about 7,815,815 (291)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Removal of Inflammatory Ascites Is Associated With Dynamic Modification of Local and Systemic Inflammation Along With Prevention of Acute Lung Injury

, 2014
Bryanna Emr, David Sadowsky, Nabil Azhar, Louis A. Gatto, Gary An, Gary F. Nieman, Yoram Vodovotz   +6 more
openalex   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Artificial intelligence for early diagnosis in emergency department. [PDF]

J Anesth Analg Crit Care
Di Fazio N, Zanza C, Longhitano Y, Voza A, Balagna R, Mosca S, Balagna P, Rossignoli R, Cerenzia S, Bertozzi G, Maiese A, Frati P, La Russa R.   +12 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Four Biomarkers Linked to Activation of Cluster of Differentiation 8–Positive Lymphocytes Predict Clinical Outcomes in Pediatric Acute Liver Failure

, 2020
Mike A. Leonis, Alexander Miethke, Lin Fei, Sean Maynor, Catherine A. Chapin, Jacob J. Bleesing, Estella M. Alonso, Robert H. Squires, for the Pediatric Acute Liver Failure Study Group   +8 more
openalex   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Natural polymer based drug-loaded hydrogel platform for comprehensive care of acute spinal cord injury

Mingyu Zhang, Chunyu Xiang, Xin Zhen, Wenqi Luo, Xiaodong He, Fuzheng Guo, Renrui Niu, Wanguo Liu, Rui Gu   +8 more
openalex   +1 more source

Effects of different triglyceride‑lowering therapies in patients with hypertriglyceridemia‑induced acute pancreatitis

, 2020
Shanshan Yu, Dongqi Yao, Xianquan Liang, Kui Jin, Yangyang Fu, Danyu Liu, Lili Zhang, Jing Yang, Xiao Song, Jun Xu, Xuezhong Yu   +10 more
openalex   +2 more sources

Acute respiratory illness in Adelaide children: breast feeding modifies the effect of passive smoking. [PDF]

, 1990
Alistair Woodward, Robert M. Douglas, Neil M.H. Graham, Helen Miles   +3 more
openalex   +1 more source