Results 221 to 230 of about 7,815,815 (291)

De Garengeot hernia presenting with acute appendicitis: a rare dual pathology and surgical challenge: a case report. [PDF]

J Surg Case Rep
Aljohani E.
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Sensitivity of Acute Leukemia Cells to Cytarabine Is a Correlate of Cellular es Nucleoside Transporter Site Content Measured by Flow Cytometry With SAENTA-Fluorescein [PDF]

, 1997
Wendy P. Gati, Alan R. P. Paterson, Loree Larratt, A. Robert Turner, Andrew R. Belch   +4 more
openalex   +1 more source

Exploring and Modifying BarrieRs to enhance ACcess to mental health support for Ethnic minority Children and Young People (CYP) in acute paediatric settings (EMBRACE) in England: a realist review protocol. [PDF]

BMJ Open
Da-Silva-Ellimah M, Darko N, Kotera Y, Sayal K, Manning JC.   +4 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Acute Severe Ulcerative Colitis: An International Delphi Consensus on Clinical Trial Design and Endpoints

Sailish Honap, Vipul Jairath, Bruce E. Sands, Parambir S. Dulai, Peter Higgins, Peter De Cruz, Ana Gutiérrez, Paulo Gustavo Kotze, Byong Duk Ye, Taku Kobayashi, Richard B. Gearry, Pablo A. Olivera, Aurélien Amiot, Mahmoud Mosli, Sameer Al Awadhi, Jonas Halfvarson, Kamal Patel, Shaji Sebastian, Silvio Danese, Laurent Peyrin-Biroulet   +19 more
openalex   +1 more source

A phase 2 randomized controlled trial of oral resistant starch supplements in the prevention of acute radiation proctitis in patients treated for cervical cancer

, 2019
Balu Krishna Sasidharan, Balamurugan Ramadass, Prakash Viswanathan, Prasanna Samuel, Mahasampath Gowri, Srinivasan Pugazhendhi, Banumathi Ramakrishna   +6 more
openalex   +1 more source

More than just appendicitis: incidental detection of a serrated polyp with malignant potential. [PDF]

J Surg Case Rep
Malik KA, Asfour NA, Jarboa LR, Zarour A.   +3 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Clinico-Epidemiological Profile and Outcome of Acute Poisoning Patients admitted to Intensive Care Unit in A Tertiary Level Private Hospital in Bangladesh

A K M Ferdous Rahman, Zubaer Wasit Nasif, Saifullah Al Kafi, Sabrina Sultana, Md Saidul Islam   +4 more
openalex   +1 more source