Results 51 to 60 of about 7,454,292 (340)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Circulating levels of adiponectin and AdipoR expression in peripheral blood mononuclear cells are associated with lower respiratory tract Infection

Frontiers in Immunology
ObjectiveThe role of adiponectin (APN) in regulating inflammation is well recognized in metabolic disease, but the dysregulation of APN in lower respiratory tract infection (LRTI) remains controversial. We aimed to measure APN and its signaling receptors,
Qian Wang, Xuemei Wang, Danning Xu, Mengjie Jiang, Yidan Gao, Lijuan Jiang, Meilian Liu, Haoneng Tang, Lingli Tang   +8 more
doaj   +1 more source

The value of the erect abdominal radiograph for the diagnosis of mechanical bowel obstruction and paralytic ileus in adults presenting with acute abdominal pain

Journal of Medical Radiation Sciences, 2018
Introduction There is discord on the value of the erect abdominal radiograph for diagnosing acute abdominal pathologies. The erect radiograph can be uncomfortable for patients in pain and increases patient radiation dose.
Wendy Z. M. Geng, Michael Fuller, Brooke Osborne, Kerry Thoirs   +3 more
doaj   +1 more source

Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus [PDF]

, 2016
Although there are high survival rates for children with acute lymphoblastic leukaemia, their outcome is often counterbalanced by the burden of toxic effects.
Attarbaschi, Andishe, Barzilai, Shlomit, Escherich, Gabriele, Frandsen, Thomas Leth, Halsey, Christina, Hough, Rachael, Jeha, Sima, Kato, Motohiro, Liang, Der-Cherng, Mikkelsen, Torben Stamm, Moricke, Anja, Niinimaki, Riitta, Piette, Caroline, Putti, Maria Caterina, Raetz, Elizabeth, Schmiegelow, Kjeld, Silverman, Lewis B., Skinner, Roderick, Tuckuviene, Ruta, van der Sluis, Inge, Zapotocka, Ester   +20 more
core   +2 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Does Foot Massage Relieve Acute Postoperative Pain? a Literature Review [PDF]

, 2013
Purpose: This study aimed to examine the current state of knowledge regarding foot massageto determine if foot massage has an effect on relieving acute postoperative pain.Method: The following questions were used to guide this review: How does pain occur?
Chanif, C. (Chanif), Chongchareon, W. (Wimonrat), Petpichetchian, W. (Wongchan)   +2 more
core  

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Prevalence and time course of post-stroke pain: A multicenter prospective hospital-based study [PDF]

, 2015
OBJECTIVE: Pain prevalence data for patients at various stages after stroke. DESIGN: Repeated cross-sectional, observational epidemiological study. SETTING: Hospital-based multicenter study.
Barbanti, Piero, Bovi, Paolo, Candeloro, E, Cavallini, Anna, Cruccu, Giorgio, Iosa, Marco, Mancini, Alessia, Mancuso, Mauro, Monaco, Serena, Paolucci, Stefano, Pieroni, Alessio, Pieroni, Alessio, Recchia, Serena, Sessa, Maria, Strambo, Davide, Tinazzi, Michele, Toni, Danilo, Truini, Andrea   +17 more
core   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Malarial acute kidney injury

Medicine Science, 2017
Malaria has emerged as one of the top killer among infectious diseases, in the World. It is a parasitic disease of epidemiological importance in tropical countries and Malaria associated Acute Kidney Injury (MAKI) is emerging as a big Nephrological issue.
Midhun Ramesh, Balu Mohan, Praveen Murlidharan, Satish Balan   +3 more
doaj   +1 more source