Results 21 to 30 of about 205,802 (306)

Saikosaponin D Attenuates Pancreatic Injury Through Suppressing the Apoptosis of Acinar Cell via Modulation of the MAPK Signaling Pathway

Frontiers in Pharmacology, 2021
Chronic pancreatitis (CP) is a progressive fibro-inflammatory syndrome. The damage of acinar cells is the main cause of inflammation and the activation of pancreatic stellate cells (PSCs), which can thereby possibly further aggravate the apoptosis of ...
Caixia Li, Lihua Cui, Lanqiu Zhang, Lei Yang, Yuzhen Zhuo, Jialin Cui, Naiqiang Cui, Shukun Zhang   +7 more
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Chaihu Guizhi Ganjiang Decoction Ameliorates Pancreatic Fibrosis via JNK/mTOR Signaling Pathway

Frontiers in Pharmacology, 2021
Pancreatic fibrosis is a pathological characteristic of chronic pancreatitis (CP) and pancreatic cancer. Chaihu Guizhi Ganjiang Decoction (CGGD) is a traditional Chinese medicine, which is widely used in the clinical treatment of digestive diseases ...
Lihua Cui, Caixia Li, Ye Shang, Dihua Li, Yuzhen Zhuo, Lei Yang, Naiqiang Cui, Yuhong Li, Shukun Zhang   +8 more
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Histone demethylase KDM6B inhibits breast cancer metastasis by regulating Wnt/β‐catenin signaling

FEBS Open Bio, 2021
Tumor metastasis remains a major challenge for patients with breast cancer. Aberrant epigenetic factor lysine‐specific demethylase 6B (KDM6B) has been associated with tumor progression.
Jing Xun, Ruifang Gao, Botao Wang, Yifan Li, Yuan Ma, Jun Guan, Qi Zhang   +6 more
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Identification of a Four-Gene Metabolic Signature to Evaluate the Prognosis of Colon Adenocarcinoma Patients

Frontiers in Public Health, 2022
BackgroundColon adenocarcinoma (COAD) is a highly heterogeneous disease, thus making prognostic predictions uniquely challenging. Metabolic reprogramming is emerging as a novel cancer hallmark that may serve as the basis for more effective prognosis ...
Yang Zheng, Yang Zheng, Rilige Wu, Ximo Wang, Ximo Wang, Ximo Wang, Chengliang Yin   +6 more
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A novel nomogram for adult primary perihilar cholangiocarcinoma and considerations concerning lymph node dissection

Frontiers in Surgery, 2023
ObjectiveTo construct a reliable nomogram available online to predict the postoperative survival of patients with perihilar cholangiocarcinoma.MethodsData from 1808 patients diagnosed with perihilar cholangiocarcinoma between 2004 and 2015 were extracted
Qi Zhang, Qi Zhang, Zehan Liu, Zehan Liu, Shuangqing Liu, Ming Wang, Xinye Li, Jing Xun, Jing Xun, Xiangyu Wang, Qin Yang, Ximo Wang, Dapeng Zhang, Dapeng Zhang   +13 more
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The Crucial Role of PPARγ-Egr-1-Pro-Inflammatory Mediators Axis in IgG Immune Complex-Induced Acute Lung Injury

Frontiers in Immunology, 2021
BackgroundThe ligand-activated transcription factor peroxisome proliferator-activated receptor (PPAR) γ plays crucial roles in diverse biological processes including cellular metabolism, differentiation, development, and immune response.
Chunguang Yan, Chunguang Yan, Chunguang Yan, Jing Chen, Yue Ding, Zetian Zhou, Bingyu Li, Chunmin Deng, Dong Yuan, Qi Zhang, Ximo Wang   +10 more
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IgG immune complex-induced acute lung injury is ameliorated by cAMP via down-regulation of C/EBP- and AP-1-mediated transcriptions

Journal of Inflammation, 2023
Background Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS) are life threatening pulmonary diseases, and we are now lack of effective therapeutic methods. Inflammatory responses are essential for initiating ALI/
Chunguang Yan, Jing Chen, Huifang Tang, Chunmin Deng, Qi Zhang, Ximo Wang   +5 more
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The effect of ursodeoxycholic acid on the relative expression of the lipid metabolism genes in mouse cholesterol gallstone models

Lipids in Health and Disease, 2020
Background Many studies indicate that gallstone formation has genetic components. The abnormal expression of lipid-related genes could be the basis for particular forms of cholesterol gallstone disease.
Ning Fan, Ke Meng, Yuqing Zhang, Yong Hu, Donghua Li, Qiaoying Gao, Jianhua Wang, Yanning Li, Shangwei Wu, Yunfeng Cui   +9 more
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CD44 is a potential immunotherapeutic target and affects macrophage infiltration leading to poor prognosis

Scientific Reports, 2023
CD44 plays a key role in the communication of CSCs with the microenvironment and the regulation of stem cell properties. UALCAN was used to analyze the expression of CD44 in bladder cancer (BLCA) and normal tissue.
Shuangqing Liu, Zehan Liu, Aichen Shang, Jing Xun, Zongjing Lv, Siying Zhou, Cui Liu, Qi Zhang, Yuming Yang   +8 more
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Analysis of risk factors for intra-cystic hemorrhage in microwave ablation of partially cystic thyroid nodules

Frontiers in Endocrinology, 2023
ObjectiveThe aim of this study is to identify risk factors of intra-cystic hemorrhage in microwave ablation of mixed solid and cystic microwave ablation s, and to design a preoperative nomogram to predict the risk value of intraoperative bleeding with ...
Yao Fu, Yuhui Huang, Yongtai Liu, Yu Song   +3 more
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