Results 51 to 60 of about 1,906,242 (299)

Stenting of the aortic arch as an emergency palliation of aortic dissection after cardiac surgery in an infant [PDF]

, 2005
Aortic dissection with low cardiac output is an acute emergency and immediate therapy is mandatory. It is however a disease of the elderly. This article reports on an infant who developed acute aortic dissection following cardiac surgery, for whom ...
Emmel, Matthias Alexander, Brockmeier, Konrad, Sreeram, Narayanswami   +2 more
core  

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

PARTIAL THROMBOSIS OF THE FALSE LUMEN IN PATIENTS WITH ACUTE TYPE B AORTIC DISSECTION

, 2007
BACKGROUND: Patency or thrombosis of the false lumen in type B acute aortic dissection has been found to predict outcomes. The prognostic implications of partial thrombosis of the false lumen have not yet been elucidated.
FROEHLICH J, ISSELBACHER EM, FATTORI, ROSSELLA, EVANGELISTA A, LLOVET A, HUTCHISON S, SMITH DE, SUNDT T, JANUZZI JL JR, EAGLE KA, DISTANTE, ALESSANDRO, MEINHARDT G, MYRMEL T, Distante A, COOPER JV, SUZUKI T, BECKMAN J, NIENABER CA, FATTORI R, TSAI TT, INTERNATIONAL REGISTRY OF ACUTE AORTIC DISSECTION   +20 more
core   +1 more source

Acute thoracic aortic dissection (Stanford B): challenges in early detection and management [PDF]

, 2015
Background: Diagnosis of acute thoracic dissection is crucial given its potential fatal complications in delayed treatment response. Early and appropriate intervention renders obviation of futile surgery.
Ahmad Saad, Fathinul Fikri, Abdullah, Noraini Sarina   +1 more
core   +2 more sources

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Advanced Flexible Robotic Systems for the Early Diagnosis and Treatment of Cancer and Cardiovascular Diseases

Advanced Robotics Research, EarlyView.
Flexible surgical robots are advancing minimally invasive interventions for cardiovascular diseases and cancer by enabling precise navigation through complex, submillimeter anatomical pathways. This review highlights recent innovations in actuation, bio‐integrated sensing, AI‐assisted control, and friction‐reduction technologies, discusses current ...
Hermione Truong, Chi Cong Nguyen, Hannah Thuy Truong, Kefan Zhu, Adrienne Ji, James Davies, Emanuele Nicotra, Bibhu Sharma, Jingjing Wan, Patrick Pruscino, Shing Wai Wong, Hoang‐Phuong Phan, Phuoc Thien Phan, Nigel H. Lovell, Thanh Nho Do   +14 more
wiley   +1 more source

Complex thoracic aortic dissection treated by aorto-biiliac bypass and juxta-renal removal of aortic fenestrations

Radiology Case Reports, 2022
Thoracic aortic dissections are a life-threatening pathology. They occur when there is an intimal tear causing separation of the layers of the aorta. Thoracic aortic dissections can be acute or chronic and depending on the pattern of the dissection can ...
Krystal Dinh, BMed, M Trauma, Shirley Cai, MBBS, Animesh Singla, FRACS (Vasc), Vikram Puttaswamy, FRACS (Vasc)   +3 more
doaj   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Chronobiological Patterns of Acute Aortic Dissection [PDF]

Circulation, 2002
Background— Chronobiological rhythms have been shown to influence the occurrence of a variety of cardiovascular disorders. However, the effects of the time of the day, the day of the week, or monthly/seasonal changes on acute aortic dissection (AAD) have not been well studied.
R. H. Mehta, MANFREDINI, Roberto, F. Hassan, U. Sechtem, E. Bossone, J. K. Oh, J. V. Cooper, D. E. Smith, PORTALUPPI, Francesco, M. Penn, S. Hutchison, C. A. Nienaber, E. M. Isselbacher, K. A. Eagle   +13 more
openaire   +4 more sources