Results 61 to 70 of about 1,906,242 (299)

Ascending thoracic aorta dimension and outcomes in acute type B dissection (from the International Registry of Acute Aortic Dissection [IRAD])

, 2011
It is not well known if the size of the ascending thoracic aorta at presentation predicts features of presentation, management, and outcomes in patients with acute type B aortic dissection.
J. B. Froehlich, Froehlich, James B, V. S. Ramanath, Ramanath, Vijay S, C. A. Nienaber, James B. Froehlich, Santi Trimarchi, O'Gara, Patrick T, Booher, Anna M, Harris, Kevin M, Reed E. Pyeritz, International Registry of Acute Aortic Dissection (IRAD) Investi,, Anna M. Booher, J. V. Cooper, Sundt, Thoralf M, Januzzi, James L, Eric M. Isselbacher, Nienaber, Christoph A, T. M. Sundt III, Christoph A. Nienaber, James L. Januzzi, Thoralf M. Sundt, Cooper, Jeanna V, S. Demertzis, Demertzis, Stefanos, Trimarchi, Santi, Jeanna V. Cooper, Vijay S. Ramanath, K. M. Harris, Kim A. Eagle, R. E. Pyeritz, K. A. Eagle, Patrick T. O'Gara, Pyeritz, Reed E, J. L. Januzzi, Eagle, Kim A, E. M. Isselbacher, P. T. O'Gara, S. Trimarchi, Kevin M. Harris, A. M. Booher, Stefanos Demertzis, Isselbacher, Eric M, O'Gara, Patrick T, International Registry of Acute Aortic Dissection (IRAD) Investi   +44 more
core   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Outcome of acute type A aortic dissection: single-center experience from 1998 to 2007 [PDF]

, 2009
Introduction. Acute aortic dissection (AAD) is a serious disease of the aorta with high mortality and morbidity, which requires emergency surgical treatment in order to close the site of the dissection and direct blood flow into the true lumen.
Zizza A., Zaccaria S., GUIDO, Marcello, Pano M., Villani M., the Aortic Dissection Study Group   +5 more
core  

Increased Disarray of Extracellular Matrix Collagen‐I Fiber Network and Compromised Biomechanics in Aortae From Marfan‐Syndrome Mice Assessed Through Combined Opto‐Biomechatronics

Advanced Science, EarlyView.
Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit, Anika Nagel, Vanessa I. T. Zwaans, Laureen Schurr, Jonas Ahr, Michael Haug, Anna Piluso, Alexandra Sporkova, Matthias Karck, Andreas H. Wagner, Oliver Friedrich   +10 more
wiley   +1 more source

Sequential Regulation of Neurovascular Bone Regeneration in Large Bone Defects Using Black Phosphorus‐Europium Nanosheet Integrated TPMS Biomimetic Scaffold with Photo‐Controlled Ion Release

Advanced Science, EarlyView.
TPBE scaffolds, in conjunction with mild photothermal effects, effectively activate the PI3K/Akt signaling cascade, thereby promoting early neuronal differentiation and neurite growth. Short‐term (12 W) in vivo implantation studies revealed no significant pathological damage to major organs, providing preliminary evidence of the material's excellent ...
Bingqian Wang, Yuping Zhang, Xiaoning Su, Ning Liu, Hui Zeng, Bo Yang, Yang Xue, Fang Guo, Changkui Liu   +8 more
wiley   +1 more source

Diagnostic strategies for suspected acute aortic syndrome: systematic review, meta-analysis, decision-analytic modelling and value of information analysis

Health Technology Assessment
Background Acute aortic syndrome is a life-threatening condition that requires urgent diagnosis with computed tomographic angiography. Diagnostic technologies, including clinical scores and biomarkers, can be used to select patients presenting with ...
Steve Goodacre, Abdullah Pandor, Praveen Thokala, Sa Ren, Munira Essat, Shijie Ren, Mark Clowes, Graham Cooper, Robert Hinchliffe, Matthew Reed, Steven Thomas, Sarah Wilson, Catherine Fowler, Valerie Lechene   +13 more
doaj   +1 more source

Ventricular fibrillation arrest in aortic dissection presenting as myocardial injury

Radiology Case Reports
An acute aortic dissection can be a tremendously fatal vascular condition if not managed promptly. However, the symptom profile of aortic dissections can be ambiguous to numerous conditions which are more common and greater pursued by clinicians before ...
Som Singh, MD, Talal Asif, MD
doaj   +1 more source

Early and Late Mortality Predictors in Patients with Acute Aortic Dissection Type B

Cardiology Research and Practice, 2022
Background/Aim. Despite technological advances in diagnosis and treatment, in-hospital mortality with acute aortic dissection type B is still about 11%. The purpose of this study was to assess the risk factors for early and long-term adverse outcomes in ...
Ratko M. Lasica, Jovan P. Perunicic, Dejana R. Popovic, Igor B. Mrdovic, Ross A. Arena, Nebojsa L. Radovanovic, Mina R. Radosavljevic-Radovanovic, Lazar D. Djukanovic, Milika R. Asanin   +8 more
doaj   +1 more source

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source