Results 81 to 90 of about 1,906,242 (299)

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Aortic root and ascending aorta dimensions in acute aortic dissection.

, 2020
OBJECTIVES Aim of this study was to evaluate ascending aorta and aortic root dimension at acute type A dissection (acute aortic dissection) and to identify demographics elements being allied to the acute event. METHODS In a period between 2009 and 2017,
Kaufmann J, Macius E, Reuthebuch O, Koechlin L, Berdajs DA, Eckstein F, Gahl B   +6 more
core   +1 more source

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Acute type B aortic dissection: update on proper management

Journal of Acute Disease, 2014
This study aims to collect and present all current literature data on the diagnostic and therapeutic management of acute type B aortic dissection. It includes a comprehensive literature search utilizing the following keywords: ‘acute aortic dissection’, ‘
Georgios Geropapas, George Galyfos
doaj   +1 more source

Systolic anterior motion of the mitral valve associated with acute type A aortic dissection: a case report describing one-step surgery of ascending aortic replacement and interventricular septal myectomy

Surgical Case Reports, 2021
Background Systolic anterior motion of the mitral valve associated with acute type A aortic dissection is rare in daily clinical practice. The prevention of systolic anterior motion is important, because once it occurs, the hemodynamics may become ...
Naoki Yamamoto, Koji Onoda
doaj   +1 more source

Is there a place for D-dimers in acute type A aortic dissection?

, 2006
Plasma concentrations of D-dimer may prove a valuable addition in the diagnostic work-up of acute type A aortic dissection, but not as means of predicting ...
Immer, F F, Immer, Franz Ferdinand
core   +1 more source

Checkpoint‐Directed Glycoengineering Reprograms the Vascular Lumen for Siglec‐Mediated Immune Regulation

Advanced Science, EarlyView.
Checkpoint‐directed glycoengineering installs sialylated ligands on the donor vascular lumen during ex vivo preservation, creating a localized Siglec‐7/9‐engaging interface. The engineered glycocalyx suppresses immune‐cell activation, complement deposition, and microvascular injury in arterial and kidney allografts while preserving endothelial ...
Md Mohosin Rana, Javairia F. Rahim, Aaron P. Bernstein, Peyman Malek Mohammadi Nouri, Lyann Sim, Winnie Enns, Jenice M. Dumlao, Haiming D. Luo, Irina Chafeeva, Hong‐Ming Chen, Aizhou Wang, Jiao‐Jing Wang, Edward N. Schmidt, Zheng Jenny Zhang, Marcelo Cypel, Christopher Nguan, Matthew S. Macauley, Stephen G. Withers, Jonathan C. Choy, Jayachandran N. Kizhakkedathu   +19 more
wiley   +1 more source

Targeting Nupr1‐Mediated p53 Mitochondrial Sequestration Alleviates Aortic Dissection by Restoring the Gadd45b‐Dependent Survival Program

Advanced Science, EarlyView.
This study identifies Nupr1 as a crucial stress‐responsive orchestrator driving AD. Under severe stress, Nupr1 massively accumulates within mitochondria to sequester p53, triggering apoptosis and concurrently repressing the Gadd45b‐mediated survival program.
Xi Yang, Ke‐Yuan Chen, Yue Tian, Zong‐Sheng Jiang, Jian Lei, Xing‐Hui Zhuang, Jiang‐Bin Wu, Le‐Le Tang, Hao‐Yu Li, Xiao‐Hui Chen, Yue Wang, Yu‐Mei Li, Zhi‐Huang Qiu, Zi‐Wen Cai, Liang‐Wan Chen   +14 more
wiley   +1 more source

Acute aortic dissection: pathogenesis, risk factors and diagnosis

Swiss Medical Weekly, 2017
Acute aortic dissection is a rare but life-threatening condition with a lethality rate of 1 to 2% per hour after onset of symptoms in untreated patients. Therefore, its prompt and proper diagnosis is vital to increase a patient’s chance of survival and
Joanna Gawinecka, Felix Schönrath, Arnold von Eckardstein   +2 more
doaj   +1 more source

Aortic Dissection.

, 2022
Acute aortic dissection is a highly morbid condition with high mortality that requires emergent surgical evaluation and repair. The intraoperative management of acute aortic dissection requires the anesthesiologist to do far more than administer ...
Mangunta, Venkat R, MD, Stombaugh, D Keegan   +1 more
core   +1 more source