Results 151 to 160 of about 98,701 (282)

New biosensors and transgenic mice for multiplex cGMP imaging

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters, Martin Thunemann, Barbara Birk, Susanne Feil, Viacheslav O. Nikolaev, Moritz Lehners, Robert Feil   +6 more
wiley   +1 more source

Renal Denervation for Refractory Hypertension Complicated by Acute Aortic Syndrome. [PDF]

JACC Case Rep
Ye H, Qin F, Wu Z, Xu W, Zhou Q, Fu W.
europepmc   +1 more source

Left brachiocephalic venous thrombus initially presenting as acute aortic syndrome. [PDF]

J Surg Case Rep, 2023
Yang A, Seevanayagam S.
europepmc   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Acute Aortic Syndromes

Medicine, 2010
Karim Ratib, Gurbir Bhatia, Neal Uren, James Nolan   +3 more
  +4 more sources

Incidence, predictors and outcomes of delirium in acute aortic syndrome. [PDF]

J Cardiothorac Surg
Chen S, Luo Y, Lu X, Huang X, Lin L, Qiu S.   +5 more
europepmc   +1 more source

Novel therapeutic targets for chronic visceral pain in gastrointestinal disorders

British Journal of Pharmacology, EarlyView.
Chronic visceral pain imposes a major clinical challenge in gastroenterology and beyond, profoundly impacting patients' quality of life. However, limited understanding of its complex, multifaceted pathophysiology, encompassing both peripheral and central mechanisms, continues to impede the development of effective management strategies.
Fleur Veldman, Christopher J. Black, Andrea Shin, Daniel Keszthelyi   +3 more
wiley   +1 more source

CT Imaging Features of Acute Aortic Syndrome: A Case Series. [PDF]

Cureus
Patel N, Patel R, Patel V, Patel A, Pujara K.   +4 more
europepmc   +1 more source

Coronary Calcium Association with All-Cause Mortality in Suspected Acute Aortic Syndrome. [PDF]

Radiol Cardiothorac Imaging, 2023
Perera Molligoda Arachchige AS.
europepmc   +1 more source

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes, Florian Buehning, Tobias Lerchner, Julia Vogel, Raluca I. Mincu, Matthias Totzeck, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source