Results 1 to 10 of about 4,352,139 (301)

The GoodHope Ehlers Danlos Syndrome Clinic: development and implementation of the first interdisciplinary program for multi-system issues in connective tissue disorders at the Toronto General Hospital

open access: yesOrphanet Journal of Rare Diseases, 2021
Ehlers-Danlos Syndrome (EDS) are a heterogeneous group of genetic connective tissue disorders, and typically manifests as weak joints that subluxate/dislocate, stretchy and/or fragile skin, organ/systems dysfunction, and significant widespread pain ...
Nimish Mittal   +25 more
doaj   +1 more source

RETRACTED ARTICLE: Targeting transforming growth factor beta (TGF-β) using Pirfenidone, a potential repurposing therapeutic strategy in colorectal cancer

open access: yesScientific Reports, 2023
The modulating factors within the tumor microenvironment, for example, transforming growth factor beta (TGF-β), may limit the response to chemo and immunotherapy protocols in colorectal cancer (CRC).
Hamid Jamialahmadi   +17 more
doaj   +1 more source

Utility of the EULAR Sjögren syndrome disease activity index in Japanese children: a retrospective multicenter cohort study

open access: yesPediatric Rheumatology Online Journal, 2020
Background The European League Against Rheumatism (EULAR) Sjögren Syndrome Disease Activity Index (ESSDAI) has been utilized to assess Sjögren syndrome-related systemic involvement in adult patients. To date, however, the ESSDAI has not been validated in
Naomi Iwata   +10 more
doaj   +1 more source

Intracerebral haemorrhage in Down syndrome: protected or predisposed? [version 1; referees: 2 approved]

open access: yesF1000Research, 2016
Down syndrome (DS), which arises from trisomy of chromosome 21, is associated with deposition of large amounts of amyloid within the central nervous system.
Lewis Buss   +6 more
doaj   +1 more source

Optimized real-time fluorescence PCR assay for the detection of porcine Circovirus type 3 (PCV3)

open access: yesBMC Veterinary Research, 2020
Background Porcine circovirus type 3 (PCV3) has been an emerging porcine virus spread around the world. The conserved DNA sequence of PCV3 enabled good performance in molecular biological assays.
Lin Yuan   +9 more
doaj   +1 more source

Comparison of resting-state EEG between adults with Down syndrome and typically developing controls

open access: yesJournal of Neurodevelopmental Disorders, 2021
Background Down syndrome (DS) is the most common genetic cause of intellectual disability (ID) worldwide. Understanding electrophysiological characteristics associated with DS provides potential mechanistic insights into ID, helping inform biomarkers and
Sarah Hamburg   +3 more
doaj   +1 more source

Machine learning algorithms reveal potential miRNAs biomarkers in gastric cancer

open access: yesScientific Reports, 2023
Gastric cancer is the high mortality rate cancers globally, and the current survival rate is 30% even with the use of combination therapies. Recently, mounting evidence indicates the potential role of miRNAs in the diagnosis and assessing the prognosis ...
Hanieh Azari   +11 more
doaj   +1 more source

Amino acid changes during the early stages of tomato wilt disease (Verticillium albo-atrum)

open access: yesPlant Protection Science, 2021
Soil-borne pathogens such as Verticillium species, invade into the roots of many herbaceous and woody hosts. The xylem environment supplies these pathogens with a continuous flow of nitrogen-rich nutrition.
Geoffrey Richard Dixon
doaj   +1 more source

Frailty Screening and Detection of Geriatric Syndromes in Acute Inpatient Care: Impact on Hospital Length of Stay and 30-Day Readmissions [PDF]

open access: yesAnnals of Geriatric Medicine and Research, 2023
Background Frailty is prevalent in acute care and is associated with negative outcomes. While a comprehensive geriatric assessment to identify geriatric syndromes is recommended after identifying frailty, more evidence is needed to support this approach ...
Justin Chew   +6 more
doaj   +1 more source

Hereditary Renal Cell Carcinoma Syndromes

open access: yesSociété Internationale d’Urologie Journal, 2022
A number of germline syndromes that predispose affected individuals to develop renal cancer have been described, each with unique manifestations, histopathology, and tumor behavior.
Jodie K. Maranchie   +3 more
doaj   +1 more source

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