Results 51 to 60 of about 6,923,824 (296)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Pre-clinical evaluation of effectiveness of infusion solutions with different osmolarity during acute blood loss in experiments on rats

Сибирский научный медицинский журнал
The aim of the research was to experimentally evaluate the effectiveness of infusion solutions with different osmolarity during acute blood loss in experiments on rats. Material and methods.
I. А. Shperling, А. V. Krupin, N. K. Arokina, О. А. Rogov   +3 more
doaj   +1 more source

Postresuscitative Myocardial Impact of Anatoxin Preimmunization

Общая реаниматология, 2007
Objective: to study the impact of preimmunization with tetanus, diphtheria, and staphylococcal anatoxins on postresuscitative myocardial pathology.Materials and methods.
D. A. Yenikeyev, A. V. Chizhikov, M. A. Aleksandrov, Ye. A. Nurgaleyeva, N. V. Novgorodova   +4 more
doaj   +1 more source

An Intelligent Decision Support System for Leukaemia Diagnosis using Microscopic Blood Images [PDF]

, 2015
This research proposes an intelligent decision support system for acute lymphoblastic leukaemia diagnosis from microscopic blood images. A novel clustering algorithm with stimulating discriminant measures (SDM) of both within- and between-cluster scatter
Nauman Aslam (13538530), Hossain, Alamgir, Peng Lim, Chee, Hossain, Mohammed Alamgir, Mohammed Alamgir Hossain (16653492), Zhang, Li, Greystoke, Brigit, Stephen Todryk (65497), Chee Peng Lim (11979216), Worawut Srisukkham (16657476), Srisukkham, Worawut, Todryk, Stephen, Brigit Greystoke (420963), Aslam, Nauman, Lim, Chee Peng, Siew Chin Neoh (16671366), Chin Neoh, Siew, Neoh, Siew Chin, Li Zhang (8200)   +18 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Genome Destabilization Upon Exposure to Ionizing Radiation and During Acute Blood Loss

Общая реаниматология, 2007
The paper compares the currently available cytogenetic methods (chromosomal aberration test and micronuclear (MN) test) for the evaluation of the impact of stressors, by using ionizing radiation as an example.
V. L. Kozhura, N. V. Kondakova, S. I. Zaichkina, O. M. Rozanova   +3 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Influence of high-dose aprotinin treatment on blood loss and coagulation patterns in open-heart surgery [PDF]

, 1990
Intraoperative administration of the proteinase Inhibitor aprotinin causes reduction in blood loss and homologous blood requirement in patients undergoing cardiac surgery.
Dietrich, W., Sebening, F., Wendt, P., Spannagl, Michael, Baranky, A., Jochum, Marianne, Schramm, Wolfgang   +6 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Ascorbic acid metabolism in the organism under the lack of oxygen supply to the tissues

Journal of Education, Health and Sport, 2017
The number and ratios of the metabolites of vitamin C - ascorbic, dehydroascorbic and diketogulonic acids were studied under the action of closed space hypoxia, acute blood loss and during sleep – the conditions associated with various oxygen saturation ...
Sergiy Petrov, Oleksandr Budnyak, Kateryna Ozherelyeva, Oleksandr Bytlan, Kseniia Nikolaienko   +4 more
doaj   +3 more sources