Results 61 to 70 of about 6,923,824 (296)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The dynamics of abnormalities of the biochemical composition of bile under the influence of two-hour tourniquet limb ischemia and acute blood loss in the experiment

Journal of Education, Health and Sport, 2020
Introduction. Traumatism is one of the most current problems nowadays. Its increase is caused by the escalation in number of emergencies. In recent years the proliferation of frequency of terrorist attacks and local armed conflicts has been observed ...
I. I. Horban, A. A. Hudyma
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Loss of circadian rhythm of blood pressure following acute stroke

BMC Neurology, 2004
Background Epidemiology of acute stroke in developing countries differs from that in the developed world, for example, the age at stroke, risk factors, subtypes of stroke and prognosis. Hypertension remains a dominant risk factor and prognostic indicator
Kumari S, Namboodri KKN, Jain S, Prabhakar S   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Altered gene expression pattern in peripheral blood mononuclear cells in patients with acute myocardial infarction. [PDF]

, 2012
In the acute phase of STEMI, dozens of genes from several pathways linked with lipid/glucose metabolism, platelet function and atherosclerotic plaque stability show altered expression.
Burzynska, Beata, Kochanowski, Janusz, Michalak, Marcin, Gajda, Ewa, Winkler, Aleksandra, Maciejak, Agata, Kiliszek, Marek, Opolski, Grzegorz, Gora, Monika, Leszczynska, Agata   +9 more
core   +3 more sources

Brain-dead humans as preclinical reference models for xenotransfusion: bridging nonhuman primates and clinical applications through in vitro evaluation

Frontiers in Physiology
BackgroundXenotransfusion using genetically engineered (GE) pig red blood cells (RBCs) offers a promising solution to blood shortages, particularly in emergency settings.
Tao Li, Jinghui Li, Shuai Jin, Lizhu Liu, Hidetaka Hara, Huling Gan, Yong Wang, Yu Zhang, Songzhe He, Tiantian Zhao, Dengke Pan, Hongtao Jiang, Yi Wang   +12 more
doaj   +1 more source

Impact of intraoperative hypotension and blood loss on acute kidney injury after pancreas surgery [PDF]

Revista Brasileira de Anestesiologia
Purpose: This study aimed to investigate factors associated with postoperative Acute Kidney Injury (AKI) focusing on intraoperative hypotension and blood loss volume. Methods: This was a retrospective cohort study of patients undergoing pancreas surgery
Mitsuru Ida, Mariko Sumida, Yusuke Naito, Yuka Tachiiri, Masahiko Kawaguchi   +4 more
doaj   +3 more sources

A Quantitative Study of the Dimensional Change of Inferior Vena Cava on Computed Tomography During Acute Hemorrhage Shock in Swine

Journal of Investigative Surgery, 2020
Background: The purpose of this study was to examine the dimensional change of IVC during acute hemorrhage through a volume-controlled acute hemorrhagic shock model in swine. Methods: Volume-controlled hemorrhage was performed in 10 adult Bama mini pigs.
Yang Li, Hai-feng Qi, Le-tian Zhang, Wei-guo Zhang, Lian-yang Zhang   +4 more
doaj   +1 more source