Results 41 to 50 of about 2,214,439 (294)

Epidemiological characteristics and influencing factors of hand, foot, and mouth disease outbreaks in Jiangsu province, 2010 – 2022: a register data analysis

Zhongguo gonggong weisheng
ObjectiveTo analyze epidemiological characteristics and determinants of hand, foot, and mouth disease (HFMD) outbreaks in Jiangsu province over the period of 2010 to 2022 for developing local HFMD prevention and control measures.
Mingyang LI, Xiaoqing CHENG, Ye WEI, Huan FAN, Xuefeng ZHANG, Changjun BAO, Qingxiang SHANG, Hong JI   +7 more
doaj   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Respiratory pathogen dynamics in community fever cases: Jiangsu Province, China (2023–2024)

Virology Journal
Background Respiratory infectious diseases have the highest incidence among infectious diseases worldwide. Currently, global monitoring of respiratory pathogens primarily focuses on influenza and coronaviruses.
Fei Deng, Zhuhan Dong, Tian Qiu, Ke Xu, Qigang Dai, Huiyan Yu, Huan Fan, Haifeng Qian, Changjun Bao, Wei Gao, Liguo Zhu   +10 more
doaj   +1 more source

Focus on acute diarrhoeal disease

World Journal of Gastroenterology, 2009
Diarrhoea is an alteration of normal bowel movement characterized by an increase in the water content, volume, or frequency of stools. Diarrhoea needs to be classified according to the trends over time (acute or chronic) and to the characteristics of the stools (watery, fatty, inflammatory).
F. Baldi, M. A. Bianco, NARDONE, GERARDO ANTONIO PIO, A. Pilotto, E. Z.a.m.p.a.r.o.   +4 more
openaire   +4 more sources

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Epidemiological and etiological investigation of a rare family cluster caused by severe fever with thrombocytopenia syndrome in Anhui Province in 2023

Virology Journal
Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease discovered in the 21st century. Human-to-human transmission of the disease has been documented, but the mechanisms of transmission require further ...
Na Chu, Wan-Hang Lu, Xiu-Jie Chu, Jia-Bing Wu, Wei Chen, Lei Gong, Dan-Dan Song, Xiao-Wei Tan, Han-Bing Liu, Wen-Wen Liu, Yong Sun, Xiu-Zhi Chen, Ming Li, Xu-Xiang Liu   +13 more
doaj   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Perturbations in gut and respiratory microbiota in COVID-19 and influenza patients: a systematic review and meta-analysis

Frontiers in Medicine
ObjectivesCoronavirus disease-19 (COVID-19)/influenza poses unprecedented challenges to the global economy and healthcare services. Numerous studies have described alterations in the microbiome of COVID-19/influenza patients, but further investigation is
Xiu-Jie Chu, Dan-Dan Song, Ming-Hua Zhou, Xiu-Zhi Chen, Na Chu, Ming Li, Bao-Zhu Li, Song-Hui Liu, Sai Hou, Jia-Bing Wu, Lei Gong   +10 more
doaj   +1 more source