Results 51 to 60 of about 2,331,514 (267)

Prognosis of Long‐Term Continuous Renal Replacement Therapy and the Impact of Combined Continuous Intravenous Sodium Infusion Therapy

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi, Atsuyoshi Mita, Kosuke Sonoda, Makoto Harada, Koji Hashimoto, Hiroshi Imamura, Yuji Kamijo   +6 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A case report of human infection with avian influenza H10N3 with a complex respiratory disease history

BMC Infectious Diseases
Background On March 16th 2024, the first case of Human infection with avian influenza H10N3 since the end of the global COVID-19 Pandemic was reported in Kunming, China.
Zhenxi Zhao, Siyi Luo, Yudong Gao, Min Dai, Jun Yan, Ying Yang, Hongwei Li, Yan Zhang, Zhipeng Mao   +8 more
doaj   +1 more source

Genomic Analyses Uncover Evolutionary Features of Influenza A/H3N2 Viruses in Yunnan Province, China, from 2017 to 2022

Viruses
Influenza A viruses evolve at a high rate of nucleotide substitution, thereby requiring continuous monitoring to determine the efficacy of vaccines and antiviral drugs.
Meiling Zhang, Jienan Zhou, Ruize Ni, Xiaonan Zhao, Yaoyao Chen, Yanhong Sun, Zhaosheng Liu, Xiaoyu Han, Chunrui Luo, Xiaoqing Fu, Yong Shao   +10 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Transiently produced IgGs enable universal SARS-CoV-2 diagnosis and differentiation recent from past infections

Microbiology Spectrum
Early diagnosis and differentiating infected from vaccinated animals (DIVA) are the milestone in mitigation, control, and eradication of virus. However, the continuous evolution of new virus strains has hindered the success of many classical techniques ...
Chuchu Li, Jingzhi Li, Chen Dong, Qian Zhen, Xiaoyu Li, Lan Yang, Jingjing Cao, Xiaoxiao Kong, Hua Tian, Lu Zhou, Fengcai Zhu, Hongwei Ma, Liguo Zhu   +12 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Neutralizing Antibody-Mediated Protection from Prior Delta Variant Infection Against Omicron BA.5 Sub-Lineage Reinfection One Year Later: A Prospective Cohort Study

Vaccines
Background: Previous SARS-CoV-2 infection provides some level of protection against reinfection. However, few studies have evaluated the neutralizing antibody (NAb) response after Delta variant infection and its ability to prevent reinfection with ...
Shihan Zhang, Yin Wang, Guo Xu, Chen Dong, Hua Tian, Chuchu Li, Xiaoxiao Kong, Jiefu Peng, Haodi Huang, Aidibai Simayi, Fengcai Zhu, Jianli Hu, Ke Xu, Changjun Bao, Hui Jin, Liguo Zhu   +15 more
doaj   +1 more source

ACUTE RESPIRATORY DISEASE CARRIERS [PDF]

Journal of the American Medical Association, 1920
The prevalence of respiratory infection, especially among young adults, has been the subject of many statistical reports. Vaughan and Palmer1have shown that for the six winter months of 1915, 43 per cent, of the deaths occurring in the United States between the ages of 20 and 29 were due to this cause.
openaire   +2 more sources