Results 91 to 100 of about 12,566,425 (256)
New directions in diagnosis and treatment of canine acute pancreatitis [PDF]
, 2011 Acute pancreatitis is an important disease in companion animal medicine, and diagnostic methodology available to veterinary practitioners is often limited. Evidence based principles for the management of this common disease are also lacking.
Mansfield, Caroline S.
core
Specialization in acute care surgery in low-income and middle-income countries
, 2018 Traumatic injuries represent the highest portion of surgical conditions worldwide, and the groups most vulnerable to these injuries are disproportionately in low-income and middle-income countries (LMICs).
Yi, Sojung, Rickard, Jennifer
core +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
FoodsGiven its antioxidant effects and central nervous system benefits, we hypothesized that RJ6601 should improve neurodegeneration in the hippocampus, a region critical for cognition and the maintenance of quality of life (QoL).
Rujikarn Chaisanam +1 more
doaj +1 more source
Journal of Applied Sciences and Environmental Management, 2015 The toxicity of methanol extract of Khaya senegalensis leaves was evaluated in Clarias gariepinus over 96 h exposure. The fish were exposed to 150 mg/L. 170 mg/L. 190mg/L, 210 mg/L and 230 mg/L of the extract and a control in acute static bioassay after
OA Abui, MM Motouke
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Frontiers in MedicineBackgroundPrimary dysmenorrhea (PD) is a common gynecological disorder that significantly affects women’s work and personal lives, especially in acute episodes when immediate pain relief is often needed.
Gaoyangzi Huang +9 more
doaj +1 more source