Results 1 to 10 of about 4,986,959 (302)

Evaluation of acute and sub-acute toxicity of selected traditional antiurolithiatic medicinal plant extracts in Wistar albino rats

Toxicology Reports, 2020
Introduction: Achyranthes aspera, Chenopodium murale, Satureja punctata, Rumex abyssinicus and Aloe pulcherrima are traditionally used to treat urolithiasis in Ethiopia. However, there are limited reports on toxicity studies.
Tilahun Alelign, Dinkenesh Chalchisa, Netsanet Fekadu, Dawit Solomon, Tesfaye Sisay, Asfaw Debella, Beyene Petros   +6 more
doaj   +4 more sources

Acute and sub-acute toxicity of aqueous extract of aerial parts of Caralluma dalzielii N. E. Brown in mice and rats

Heliyon, 2019
Caralluma dalzielii N. E. Brown (Asclepiadaceae) is a cactus-like shaped shrub widely used in traditional medicine for the treatment of rheumatoid arthritis, diabetes, infertility and impotence.
Chinenye Jane Ugwah-Oguejiofor, Charles Ogbonna Okoli, Michael Oguejiofor Ugwah, Millicent Ladi Umaru, Chiedozie Smart Ogbulie, Halilu Emmanuel Mshelia, Mohammed Umar, Anoka Ayembe Njan   +7 more
doaj   +2 more sources

Acute and sub-acute toxicity assessment of methanolic stem bark extract of Khaya anthotheca (Meliaceae) in Wistar rats [PDF]

Tropical Medicine and Health
Background Khaya anthotheca (Meliaceae) is a medicinal plant with a wide range of therapeutic properties attributable mainly to the diverse limonoids it contains.
Betty Akwongo, Esezah K. Kakudidi, Anthony M. Nsubuga, Morgan Andama, Mary Namaganda, Patience Tugume, Savina Asiimwe, Godwin Anywar, Esther Katuura   +8 more
doaj   +2 more sources

Evaluation of the in vivo and in vitro safety profile of Cuscuta epithymum ethanolic extract [PDF]

Avicenna Journal of Phytomedicine, 2021
Objective: Cuscuta epithymum (CE) is one of the most popular medicinal plants in the world. However, detailed information about its toxicity is not available.
Mohammad Reza Abedini, Samaneh PAki, Mahtab Mohammadifard, Mohsen Foadoddini, Khadijeh Vazifeshenas-Darmiyan, Mehran Hosseini   +5 more
doaj   +1 more source

Proton Therapy of Prostate and Pelvic Lymph Nodes for High Risk Prostate Cancer: Acute Toxicity [PDF]

International Journal of Particle Therapy, 2021
Purpose: To assess acute gastrointestinal (GI) and genitourinary (GU) toxicities of intensity-modulated proton therapy (IMPT) targeting the prostate/seminal vesicles and pelvic lymph nodes for prostate cancer.
Richard Choo, MD, David W. Hillman, MS, Thomas Daniels, MD, Carlos Vargas, MD, Jean Claude Rwigema, MD, Kimberly Corbin, MD, Sameer Keole, MD, Sujay Vora, MD, Kenneth Merrell, MD, Bradley Stish, MD, Thomas Pisansky, MD, Brian Davis, MD, PhD, Adam Amundson, William Wong, MD   +13 more
doaj   +1 more source

CATMoS: Collaborative Acute Toxicity Modeling Suite

Environmental Health Perspectives, 2021
Background: Humans are exposed to tens of thousands of chemical substances that need to be assessed for their potential toxicity. Acute systemic toxicity testing serves as the basis for regulatory hazard classification, labeling, and risk management ...
K. Mansouri, A. Karmaus, J. Fitzpatrick, G. Patlewicz, Prachi Pradeep, Domenico Alberga, N. Alépée, Timothy E. H. Allen, Dave Allen, Vinicius M. Alves, C. Andrade, T. Auernhammer, D. Ballabio, S. Bell, E. Benfenati, S. Bhattacharya, Joyce V Bastos, S. Boyd, J. B. Brown, Stephen J. Capuzzi, Y. Chushak, Heather L. Ciallella, A. Clark, V. Consonni, Pankaj R. Daga, S. Ekins, S. Farag, M. Fedorov, D. Fourches, Domenico Gadaleta, F. Gao, J. Gearhart, Garett Goh, J. Goodman, F. Grisoni, C. Grulke, T. Hartung, Matthew J. Hirn, Pavel Karpov, A. Korotcov, G. Lavado, Michael S. Lawless, Xinhao Li, T. Luechtefeld, F. Lunghini, G. Mangiatordi, G. Marcou, D. Marsh, T. Martin, A. Mauri, E. Muratov, G. Myatt, Dac-Trung Nguyen, O. Nicolotti, R. Note, Paritosh Pande, Amanda K. Parks, Tyler Peryea, A. Polash, R. Rallo, A. Roncaglioni, C. Rowlands, P. Ruiz, Daniel P. Russo, A. Sayed, Risa R. Sayre, Timothy K Sheils, Charles Siegel, A. C. Silva, A. Simeonov, S. Sosnin, Noel Southall, J. Strickland, Yun Tang, B. Teppen, I. Tetko, Dennis G. Thomas, Valery Tkachenko, R. Todeschini, Cosimo Toma, Ignacio Tripodi, Daniela Trisciuzzi, A. Tropsha, A. Varnek, K. Vukovic, Zhongyu Wang, Liguo Wang, K. Waters, Andrew J. Wedlake, Sanjeeva J. Wijeyesakere, Daniel M. Wilson, Zijun Xiao, Hongbin Yang, Gergely Zahoránszky-Kőhalmi, A. Zakharov, Fagen F Zhang, Zhen Zhang, Tongan Zhao, Hao Zhu, Kimberley M. Zorn, W. Casey, N. Kleinstreuer   +101 more
semanticscholar   +1 more source

Evaluation of the Acute and Sub-Acute Oral Toxicity of Jaranol in Kunming Mice

Frontiers in Pharmacology, 2022
Background: Jaranol has shown a wide range of pharmacological activities; however, no study has yet examined in vivo toxicity. The study aimed to investigate the oral acute and sub-acute toxicity of jaranol in mice.Methods: The acute toxicity was ...
Tianlong Liu, Yao Zhang, Jing Liu, Junwen Peng, Xin Jia, Xin Jia, Xin Jia, Yunfeng Xiao, Yunfeng Xiao, Lanbing Zheng, Yu Dong, Yu Dong   +11 more
doaj   +1 more source

Interspecies Quantitative Structure-Toxicity-Toxicity Relationships for Predicting the Acute Toxicity of Organophosphorous Compounds

Chemistry Proceedings, 2021
Median lethal concentration values are commonly used to express the relative risk related to the acute toxicity of chemicals. In this paper, we considered rat and mouse acute toxicity (LD50) data of organophosphorous compounds (OPs) with diverse ...
Gheorghe Ilia, Ana Borota, Simona Funar-Timofei   +2 more
doaj   +1 more source

Acute Methylenedioxypyrovalerone Toxicity [PDF]

Journal of Medical Toxicology, 2014
The objective of this study was to characterize the acute clinical effects, laboratory findings, complications, and disposition of patients presenting to the hospital after abusing synthetic cathinone. We conducted a retrospective multicenter case series of patients with synthetic cathinone abuse by searching for the terms bath salts, MDPV ...
Blake A, Froberg, Michael, Levine, Michael C, Beuhler, Bryan S, Judge, Philip W, Moore, Kristin M, Engebretsen, Nathanael J, Mckeown, Christopher D, Rosenbaum, Amy C, Young, Daniel E, Rusyniak   +9 more
openaire   +2 more sources

PredAOT: a computational framework for prediction of acute oral toxicity based on multiple random forest models

BMC Bioinformatics, 2023
Background Acute oral toxicity of drug candidates can lead to drug development failure; thus, predicting the acute oral toxicity of small compounds is important for successful drug development.
Jae Yong Ryu, Woo Dae Jang, Jidon Jang, Kwang-Seok Oh   +3 more
doaj   +1 more source