Results 21 to 30 of about 4,986,959 (302)

Toxicological evaluation of Bauhinia variegata Linn. for estimating the neurological, hematological and physical alterations in the albino mice

Environment Conservation Journal, 2016
The objective of present study is to establish the safety standards and the evaluation of potential toxicity of Bauhinia variegata Linn. Dried stem bark extract of Bauhinia variegata were evaluated for toxicity studies.
Ashwani Kumar, Vikas Anand2, R.C. Dubey, Kapil K. Goel   +3 more
doaj   +1 more source

Intensity-modulated fractionated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): acute toxicity findings from an international, randomised, open-label, phase 3, non-inferiority trial

The Lancet Oncology, 2019
Summary Background Localised prostate cancer is commonly treated with external-beam radiotherapy. Moderate hypofractionation has been shown to be non-inferior to conventional fractionation.
D. Brand, D. Brand, A. Tree, A. Tree, P. Ostler, H. Voet, A. Loblaw, W. Chu, D. Ford, S. Tolan, Suneil Jain, Alexander S. Martin, J. Staffurth, P. Camilleri, K. Kancherla, J. Frew, A. Chan, I. Dayes, D. Henderson, S. Brown, C. Cruickshank, S. Burnett, A. Duffton, C. Griffin, V. Hinder, K. Morrison, K. Morrison, O. Naismith, E. Hall, N. V. As, N. V. As, D. Dodds, E. Lartigau, S. Patton, A. Thompson, M. Winkler, P. Wells, T. Lymberiou, D. Saunders, M. Vilarino-Varela, P. Vavassis, T. Tsakiridis, R. Carlson, G. Rodrigues, J. Tanguay, S. Iqbal, S. Morgan, A. Mihai, A. Li, O. Din, M. Panadés, R. Wade, Y. Rimmer, J. Armstrong, N. Oommen   +54 more
semanticscholar   +1 more source

Assessment of the acute and sub-acute toxicity of the ethanolic extract of the aerial parts of Crassocephalum rabens (Asteraceae) in rats

Toxicology Reports, 2022
This pioneering study was to assess the acute and sub-acute toxicity of the ethanolic extract of the aerial parts of Crassocephalum rabens (Asteraceae) in rats. C.
Pang-Kuei Hsu, Yueh-Ting Tsai, Yu-Cheng Lin, Chen-Meng Kuan   +3 more
doaj   +1 more source

Ingestion and contact with polyethylene microplastics does not cause acute toxicity on marine zooplankton.

Journal of Hazardous Materials, 2018
Toxicity of polyethylene microplastics (PE-MP) of size ranges similar to their natural food to zooplanktonic organisms representative of the main taxa present in marine plankton, including rotifers, copepods, bivalves, echinoderms and fish, was evaluated.
R. Beiras, J. Bellas, J. Cachot, Bettie Cormier, Xavier Cousin, Xavier Cousin, Magnus Engwall, C. Gambardella, F. Garaventa, Steffen Keiter, F. Bihanic, S. López-Ibáñez, V. Piazza, D. Rial, Tania Tato, L. Vidal-Liñán   +15 more
semanticscholar   +1 more source

STopTox: An in Silico Alternative to Animal Testing for Acute Systemic and Topical Toxicity

Environmental Health Perspectives, 2020
Background: Modern chemical toxicology is facing a growing need to Reduce, Refine, and Replace animal tests (Russell 1959) for hazard identification.
Joyce V. B. Borba, Vinicius M. Alves, R. Braga, D. Korn, Kirsten E. Overdahl, A. C. Silva, Steven U S Hall, Erik Overdahl, J. Strickland, D. Allen, N. Kleinstreuer, C. Andrade, E. Muratov, A. Tropsha   +13 more
semanticscholar   +1 more source

Evaluation of Acute and Repeated Dose Oral Toxicity of Phoenix dactylifera L. Pollen Methanolic Extract in Rats

Journal of Tropical Pharmacy and Chemistry
Pollen of the date palm (Phoenix dactylifera L.) has been used for thousands of years as a traditional herbal medicine for improving fertility. However, safety of plant-derived materials is an important concern to human health, and herbal remedies ...
Musab A. M. Abdelrahim, Elhadi M. M. Ahmed   +1 more
doaj   +1 more source

Systematic Review of the Relationship between Acute and Late Gastrointestinal Toxicity after Radiotherapy for Prostate Cancer

Prostate Cancer, 2015
A small but meaningful percentage of men who are treated with external beam radiation therapy for prostate cancer will develop late gastrointestinal toxicity. While numerous strategies to prevent gastrointestinal injury have been studied, clinical trials
Matthew Sean Peach, Timothy N. Showalter, Nitin Ohri   +2 more
doaj   +1 more source

Advances in acute toxicity testing: strengths, weaknesses and regulatory acceptance

Interdisciplinary Toxicology, 2018
Safety assessment of chemicals, pharmaceuticals, food and food ingredients, cosmetics, industrial products is very crucial prior to their approval for human uses.
E. Erhirhie, C. Ihekwereme, E. Ilodigwe
semanticscholar   +1 more source

Proton beam therapy delivered using pencil beam scanning vs. passive scattering/uniform scanning for localized prostate cancer: Comparative toxicity analysis of PCG 001-09

Clinical and Translational Radiation Oncology, 2019
Background and purpose: Patient-level benefits of proton beam therapy (PBT) relative to photon therapy for prostate cancer (PC) continue to be the focus of debate. Although trials comparing the two modalities are underway, most are being conducted using “
Mark V. Mishra, Rahul Khairnar, Søren M. Bentzen, Gary Larson, Henry Tsai, Christopher Sinesi, Carlos Vargas, George Laramore, Carl Rossi, Lane Rosen, Mingyao Zhu, William Hartsell   +11 more
doaj   +1 more source

An Assessment of the Oral and Inhalation Acute Toxicity of Nickel Oxide Nanoparticles in Rats

Nanomaterials, 2023
Nickel oxide nanoparticles (NiO NPs) have been the focus of many toxicity studies. However, acute toxicity studies that identify toxicological dose descriptors, such as an LC50 or LD50, are lacking.
Tara Lyons-Darden, Jason L. Blum, Mark W. Schooley, Melissa Ellis, Jennifer Durando, Daniel Merrill, Adriana R. Oller   +6 more
doaj   +1 more source