Improved survival after acute graft-versus-host disease diagnosis in the modern era [PDF]
Haematologica, 2017 A cute graft-versus-host disease remains a major threat to a successful outcome after allogeneic hematopoietic cell transplantation. While improvements in treatment and supportive care have occurred, it is unknown whether these advances have resulted in ...
Hanna J. Khoury +46 more
doaj +5 more sources
Validation of Minnesota acute graft-versus-host disease Risk Score [PDF]
Haematologica, 2020 Using multicenter data, we developed a novel acute graft-versus-host disease Risk Score which more accurately predicts response to steroid treatment, survival and transplant related mortality than other published risk scores based upon clinical grading ...
Margaret L. MacMillan +5 more
doaj +2 more sources
Effectiveness and safety of lower dose prednisone for initial treatment of acute graft-versus-host disease: a randomized controlled trial [PDF]
Haematologica, 2015 We conducted a phase III study to test the hypothesis that initial therapy with “lower dose” prednisone is effective and safe for patients with newly diagnosed acute graft-versus-host disease.
Marco Mielcarek +9 more
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Breakdown of thymic tolerance - an etiologic link between acute and chronic graft-versus-host disease [PDF]
, 2014 Allogeneic haematopoietic stem cell transplantation (HSCT) is the standard therapy for many disorders of the haematological system. Its use is limited by the major complication acute graft-versus-host disease (GVHD). Development of acute GVHD predisposes
Dertschnig, Simone
core +1 more source
Chronic graft-versus-host disease: clinical presentation of multiple lesions of lichenoid and atrophic pattern [PDF]
Anais Brasileiros de Dermatologia, 2013 Graft-versus-host disease is observed mainly in recipients of hematopoietic cell transplantation and is expressed by cutaneous or systemic signals and symptoms. Graft-versus-host disease is clinically classified as acute or chronic.
Luiza Vasconcelos +6 more
doaj +1 more source
Donor single nucleotide polymorphism in ACAT1 affects the incidence of graft-versus-host disease after bone marrow transplantation [PDF]
, 2020 Acyl-coenzyme A: cholesterol acyltransferase 1 (ACAT1) is an enzyme that converts cholesterol to cholesteryl esters. A recent in vivo study reported that inhibiting ACAT1 enzyme activity upregulates the membrane cholesterol levels of T cells, enhancing ...
Okuno, Shingo +12 more
core +1 more source
Haematologica, 2012 Background The National Institutes of Health Consensus Conference proposed the term “overlap” graft-versus-host disease to describe the situation when both acute and chronic graft-versus-host disease are present.Design and Methods We examined whether the
Joseph Pidala +12 more
doaj +1 more source
Human Mesenchymal Stem Cell Therapy for Acute Graft Versus Host Disease [PDF]
, 2016 Acute graft versus host disease (GVHD) is the most critical complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The understanding of major histocompatibility complex (MHC) and the development of acute GVHD prophylaxis have ...
Miura, Yasuo, Yoshioka, Satoshi
core +1 more source
Haematologica, 2014 The prognosis of patients with relapsed acute myeloid leukemia after allogeneic transplantation is poor. We hypothesized that initial disease control by effective cytoreduction, followed by rapid induction of a profound allo-immune response by donor ...
Matthias Eefting +7 more
doaj +1 more source
Adoptive Immunotherapy in Chimeras with Donor Lymphocytes [PDF]
, 2003 Allogeneic stem cell transplantation has a well-defined indication in the treatment of hematological malignancies. The beneficial immune effect of allogeneic marrow transplantation has long been known, but only recently have methods been developed to ...
Kolb, Hans-Jochem +8 more
core +1 more source