Results 251 to 260 of about 8,348,024 (289)

The Pathophysiology of Acute Graft-versus-Host Disease

International Journal of Hematology, 2003
The pathophysiology of acute graft-versus-host disease (GVHD) is a complex process that can be conceptualized in three phases. In the first phase, high-dose chemoradiotherapy causes damage to host tissues, including a self-limited burst of inflammatory cytokines such as tumor necrosis factor (TNF)-alpha and interleukin 1.
James L M, Ferrara, Kenneth R, Cooke, Takanori, Teshima   +2 more
openaire   +2 more sources

Immunobiology of acute graft-versus-host disease

Blood Reviews, 2003
Graft-versus-host disease (GVHD) has been the primary limitation to the wider application of allogeneic bone marrow transplantation (BMT). The immunobiology of acute GVHD is complex and can be conceptualized to be a three-step process. In step 1, the conditioning regimen (irradiation and/or chemotherapy) leads to the damage and activation of host ...
Pavan, Reddy, James L M, Ferrara
openaire   +2 more sources

Acute Follicular Graft-versus-Host Disease

Dermatology, 2009
We documented by clinical, histopathologic and immunohistochemical analysis a case of acute follicular graft-versus-host disease (GVHD), in which an erythematous-to-violaceous follicular papular eruption constituted the major clinical pattern of cutaneous involvement.
M, Tani, A, Adachi
openaire   +2 more sources

Acute Ocular Graft-versus-Host Disease

New England Journal of Medicine, 2017
A 21-year-old man with refractory acute myeloid leukemia presented with itching and tearing in both eyes 1 month after hematopoietic stem-cell transplantation. A diagnosis of acute ocular graft-versus-host disease was made.
Regine, Braun, Ernst, Holler
openaire   +2 more sources

Acute graft-versus-host disease

1990
Acute graft-versus-host disease (GVHD) occurs after allogeneic hematopoietic stem cell transplant and is a reaction of donor immune cells against host tissues. Activated donor T cells damage host epithelial cells after an inflammatory cascade that begins with the preparative regimen.
openaire   +2 more sources

Targeting the chemokines in acute graft-versus-host disease [PDF]

Frontiers in Immunology
Huafang Wang
exaly   +2 more sources

Acute and chronic graft-versus-host disease

Current Opinion in Oncology, 1993
Acute graft-versus-host disease is a two-step process. First, allorecognition of histocompatibility antigen activates T lymphocytes, which releases several cytokines, including interleukin-1 and tumor necrosis factor. Understanding of this activity resulted in new therapeutic approaches.
openaire   +2 more sources

Acute Graft-versus-Host Disease

2008
With a successful marrow transplant, the recipient’s lymphohemopoietic cells are replaced by donor derived cells. Thus, in contrast to solid organ transplantation where the recipient’s immune system remains in place and attempts at immu-nosuppression are aimed at preventing the reaction of recipient cells against the transplanted organ, the directions ...
Martin Benesch, H. Joachim Deeg
openaire   +1 more source

Acute Graft-Versus-Host Disease (GVHD)

2015
Despite advances in human leukocyte antigen (HLA) typing, acute graft-versus-host disease (aGVHD) remains a leading cause of morbidity and mortality among allogeneic hematopoietic stem cell transplant (HSCT) recipients. It is estimated that 30–50 % of patients who receive stem cell products from HLA-identical siblings will develop grades 2–4 aGVHD ...
openaire   +1 more source

Mucoscopy in acute graft‐versus‐host disease

Oral Diseases, 2020
Grażyna Kamińska‐Winciorek, Anastazja Szlauer‐Stefańska   +1 more
openaire   +2 more sources