Results 121 to 130 of about 8,879,078 (347)

Antimicrobial use in European acute care hospitals: results from the second point prevalence survey (PPS) of healthcare-associated infections and antimicrobial use, 2016 to 2017

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2018
Antimicrobial agents used to treat infections are life-saving. Overuse may result in more frequent adverse effects and emergence of multidrug-resistant microorganisms.
D. Plachouras, T. Kärki, S. Hansen, S. Hopkins, O. Lyytikäinen, M. Moro, J. Reilly, Peter Zarb, W. Zingg, P. Kinross, K. Weist, D. Monnet, C. Suetens   +12 more
semanticscholar   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Evidence on Fall and Injurious Fall Prevention Interventions in Acute Care Hospitals

Journal of Nursing Administration, 2019
Falls and injurious falls are a major safety concern for patient care in acute care hospitals. Inpatient falls and injurious falls can cause extra financial burden to patients, families, and healthcare facilities.
Y. Zhao, M. Bott, Jianghua He, Heejung Kim, S. Park, N. Dunton   +5 more
semanticscholar   +1 more source

Annual report of the Massachusetts Memorial Hospitals

, 1959
Annual report of the Massachusetts Memorial ...
Massachusetts Memorial Hospitals
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

[Erratum] Escherichia coli endocarditis and cardiac abscess: a rare presentation in a patient with a prosthetic aortic valve

European Journal of Case Reports in Internal Medicine, 2023
Ishan J. Chavada, Ramsha Anwar, Michael W. Dumont, Mohammed Khutubuddin   +3 more
doaj   +1 more source

Managing energy retrofit of acute hospitals and community clinics through EPC contracting: the MARTE project.

, 2015
Acute hospitals and community clinics contribute to energy consumption and have a negative environmental impact. This is mainly due to the age of the buildings, a poor level of energy efficiency and a basic maintenance plan.
A. Carbonari, R. Fioretti, M. Lemma, P. Principi   +3 more
semanticscholar   +1 more source

Trends in Emergency Department Visits and Admission Rates Among US Acute Care Hospitals

JAMA Internal Medicine, 2018
This observational study describes trends in emergency department visits and admission rates among US acute care hospitals using data from the National Emergency Department Survey.
Michelle P. Lin, O. Baker, L. Richardson, J. Schuur   +3 more
semanticscholar   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source