Results 81 to 90 of about 3,618,629 (304)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Relationship between levels of inflammatory cytokines in the genital tract and CD4+ cell counts in women with acute HIV-1 infection. [PDF]

, 2008
Inflammatory responses at mucosal surfaces after human immunodeficiency virus type 1 (HIV-1) transmission may influence disease outcome. We evaluated levels of interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha, IL-8, IL-10, and IL-12 in genital ...
van Loggerenberg, Francois, Passmore, Jo-Ann Shelley., Bebell, Lisa M., Mlisana, Koleka Patience., Bebell, Lisa M, Iriogbe, Itua, Karim, Quarraisha Abdool, Williamson, Carolyn, Karim, Salim Abdool, Iriogbe, Itua., Abdool Karim, Quarraisha., Mlisana, Koleka, van Loggerenberg, Francois., Abdool Karim, Salim Safurdeen., Passmore, Jo-Ann, Williamson, Carolyn.   +15 more
core   +1 more source

Etiological Structure and Features of a Symbiotic Relationship Dominates Agents Acute Intestinal Infections in the North-Eastern Regione of Ukraine

Эпидемиология и вакцинопрофилактика, 2015
The article shows a retrospective epidemiological analysis of the incidence of acute intestinal diseases in 2004 – 2013 in Sumy region. The etiological structure was studied.
N. G. Malysh, E. V. Holodilo, N. D. Chemych, A. M. Zaritsky   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

DIARRHEA IN EARLY LIFE: PROGRESS IN DIAGNOSIS AND CONTROL OF DISEASE [PDF]

, 2010
Diarrheal diseases occurring in early life (< 3 years) are an heterogeneous group of abnormalities including gastrointestinal infections, food hypersensitivity and allergy, immune dysregulation, and primary abnormalities of the enterocyte.
Terrin, Gianluca
core   +1 more source

Cyclospora cayetanensis infection in transplant traveller: a case report of outbreak

Parasites & Vectors, 2015
Background Cyclospora cayetanensis is a protozoan parasite causing intestinal infections. A prolonged course of infection is often observed in immunocompromised individuals. In Europe, less than 100 cases of C.
Małgorzata Bednarska, Anna Bajer, Renata Welc-Falęciak, Andrzej Pawełas   +3 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Biochemical markers of health for children with poor anthropometric status in urban Nepal [PDF]

, 2001
This study examines the relationship between poor anthropometric status and biochemical markers in children in urban poor Nepal. To date, no study has examined poor nutritional status in the urban poor children in relation to biochemical markers to ...
Goto, Rie
core  

Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice. [PDF]

, 2012
Relapsing C. difficile disease in humans is linked to a pathological imbalance within the intestinal microbiota, termed dysbiosis, which remains poorly understood. We show that mice infected with epidemic C.
Parkhill Julian, Duncan Sylvia H., Deakin, Laura J., Thomas R. Connor (125272), Schreiber Fernanda, Brandt, Cordelia, Pickard Derek J., Flint, Harry J, Harry J. Flint (125298), Parkhill, J, Flint, Harry James, Trevor D. Lawley (125265), Simon Clare, Roland Rad (125284), David Goulding (125280), Julian Parkhill (30393), Claire Raisen (125275), Schreiber, F, Clare Simon, Taane G Clark, Deakin Laura J., Connor Thomas R., Taane G. Clark (106263), Clark, Taane G., Gordon Dougan, Duncan, SH, Sylvia H. Duncan (125296), Stares, Mark D., Raisen Claire, Roland Rad, Trevor D Lawley, Rad, Roland, Derek J. Pickard (125293), Sylvia H Duncan, Walker Alan W., Harry J Flint, Goulding David, Rad, R, Derek J Pickard, Deakin, LJ, Schreiber, Fernanda, Clark, Taane G, Clark, TG, Rad Roland, Walker, Alan W, Flint Harry J., Goulding, David, Alan W. Walker (50247), Raisen, C, Stares, MD, Pickard, Derek J, Flint, Harry J., Lawley, Trevor D, Deakin, Laura J, Connor, Thomas R, Claire Raisen, Brandt, C, Walker, AW, Mark D Stares, Walker, Alan W., Duncan, Sylvia H, Dougan Gordon, Connor, Thomas Richard, Clare, Simon, Pickard, Derek J., Laura J Deakin, Fernanda Schreiber, Fernanda Schreiber (85280), Lawley, TD, Clare, S, Julian Parkhill, Alan W Walker, David Goulding, Lawley, Trevor D., Raisen, Claire, Mark D. Stares (125271), Cordelia Brandt (125287), Laura J. Deakin (125290), Brandt Cordelia, Dougan, Gordon, Pickard, DJ, Duncan, Sylvia H., Parkhill, Julian, Simon Clare (125268), Clark Taane G., Flint, HJ, Gordon Dougan (30395), Thomas R Connor, Stares Mark D., Stares, Mark D, Goulding, D, Cordelia Brandt, Connor, TR, Dougan, G, Lawley Trevor D.   +94 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source