Results 221 to 230 of about 359,319 (260)

Timing of kidney replacement therapy initiation in acute kidney injury

Current Opinion in Nephrology & Hypertension, 2021
Purpose of review Over the past 5 years, four major randomized controlled trials were published informing our practice on the optimal timing for kidney replacement therapy (KRT) initiation in critically ill patients with acute kidney injury (AKI).
Alejandro Y, Meraz-Muñoz, Sean M, Bagshaw, Ron, Wald   +2 more
openaire   +2 more sources

Small Molecules as a Source for Acute Kidney Injury Therapy

SSRN Electronic Journal, 2021
Acute kidney injury (AKI) is a sudden loss of kidney function that causes a rise in serum creatinine and a decrease in urine output, which leads to high morbidity and mortality. However, effective therapeutic drugs have not yet been developed due to the poor understanding of the cellular and molecular mechanisms of AKI.
Ya-Long, Feng, Yang, Yang, Hua, Chen
openaire   +2 more sources

Mitochondria-targeted therapies for acute kidney injury

Expert Reviews in Molecular Medicine, 2014
Acute kidney injury (AKI) is a serious clinical condition with no effective treatment. Tubular cells are key targets in AKI. Tubular cells and, specifically, proximal tubular cells are extremely rich in mitochondria and mitochondrial changes had long been known to be a feature of AKI.
Luis Carlos, Tábara, Jonay, Poveda, Catalina, Martin-Cleary, Rafael, Selgas, Alberto, Ortiz, Maria D, Sanchez-Niño   +5 more
openaire   +2 more sources

Therapy of acute kidney injury in the perioperative setting

Current Opinion in Anaesthesiology, 2017
The current review analyzes the current pharmacologic approaches in cardiac surgery-associated acute kidney injury and renal replacement/support therapies.Hemodynamic management and promising therapies, including atrial natriuretic peptide, calcium sensitizer inodilators, and mesenchymal stem cells have been discussed.
Romagnoli S., Ricci Z., Ronco C.
openaire   +2 more sources

MEDICAL THERAPY OF ACUTE KIDNEY INJURY

Acta Clinica Belgica, 2007
Pharmacologic interventions for the prevention and therapy of acute kidney injury (AKI) can be roughly divided into 2 main strategies: Optimising renal perfusion and modulation of intrarenal pathophysiological mechanisms, i.e. formation of free oxygen radicals, inflammation, tubular cast formation and renal (tubular) regeneration.
openaire   +2 more sources

Sequential Therapy of Acute Kidney Injury with a DNA Nanodevice

Nano Letters, 2021
The high demand for acute kidney injury (AKI) therapy calls the development of multifunctional nanomedicine for renal management with programmable pharmacokinetics. Here, we developed a renal-accumulating DNA nanodevice with exclusive kidney retention for longitudinal protection of AKI in different stages in a renal ischemia-reperfusion (I/R) model ...
Qian Chen, Fei Ding, Shuangye Zhang, Qian Li, Xiaoguo Liu, Haiyun Song, Xiaolei Zuo, Chunhai Fan, Shan Mou, Zhilei Ge   +9 more
openaire   +2 more sources

Renal Replacement Therapy in Pediatric Acute Kidney Injury

The Indian Journal of Pediatrics, 2020
Acute kidney injury (AKI) is common in critically ill children and affects nearly 30-40% of patients admitted to the pediatric intensive care unit (ICU). Even with technological advances in critical care and dialysis, there is a high mortality rate of 66.8% to 90% in ICU patients.
Sidharth Kumar Sethi, Ronith Chakraborty, Hirva Joshi, Rupesh Raina   +3 more
openaire   +2 more sources

Goal-directed therapy and development of acute kidney injury

European Journal of Anaesthesiology, 2021
info:eu-repo/semantics ...
Joosten, Alexandre, Alexander, Brenton, Duranteau, Jacques, Legrand, Matthieu   +3 more
openaire   +3 more sources

Anticoagulation in patients with acute kidney injury undergoing kidney replacement therapy

Pediatric Nephrology, 2021
Kidney replacement therapy (KRT) is used to provide supportive therapy for critically ill patients with severe acute kidney injury and various other non-renal indications. Modalities of KRT include continuous KRT (CKRT), intermittent hemodialysis (HD), and sustained low efficiency daily dialysis (SLED). However, circuit clotting is a major complication
Rupesh Raina, Ronith Chakraborty, Andrew Davenport, Patrick Brophy, Sidharth Sethi, Mignon McCulloch, Timothy Bunchman, Hui Kim Yap   +7 more
openaire   +2 more sources

Timing of Renal Replacement Therapy for Acute Kidney Injury

Journal of Intensive Care Medicine, 2018
Acute kidney injury (AKI) is common in critically ill patients and associated with increased morbidity and mortality. With the increased use of renal replacement therapy (RRT) for severe AKI, the optimal time for initiation of RRT has become one of the most probed and debated topic in the field of nephrology and critical care.
Nithin, Karakala, Ashita J, Tolwani
openaire   +2 more sources