Results 251 to 260 of about 501,514 (307)

Timing of kidney replacement therapy initiation for acute kidney injury

Cochrane Database of Systematic Reviews, 2022
Acute kidney injury (AKI) is a common condition among patients in intensive care units (ICUs) and is associated with high numbers of deaths. Kidney replacement therapy (KRT) is a blood purification technique used to treat the most severe forms of AKI. The optimal time to initiate KRT so as to improve clinical outcomes remains uncertain.
Fayad, Alicia Isabel, Buamscha, Daniel G., Ciapponi, Agustín   +2 more
openaire   +3 more sources

Mitochondria-targeted therapies for acute kidney injury

Expert Reviews in Molecular Medicine, 2014
Acute kidney injury (AKI) is a serious clinical condition with no effective treatment. Tubular cells are key targets in AKI. Tubular cells and, specifically, proximal tubular cells are extremely rich in mitochondria and mitochondrial changes had long been known to be a feature of AKI.
Luis Carlos, Tábara, Jonay, Poveda, Catalina, Martin-Cleary, Rafael, Selgas, Alberto, Ortiz, Maria D, Sanchez-Niño   +5 more
openaire   +2 more sources

Renal Replacement Therapy in Pediatric Acute Kidney Injury

The Indian Journal of Pediatrics, 2020
Acute kidney injury (AKI) is common in critically ill children and affects nearly 30-40% of patients admitted to the pediatric intensive care unit (ICU). Even with technological advances in critical care and dialysis, there is a high mortality rate of 66.8% to 90% in ICU patients.
Sidharth Kumar Sethi, Ronith Chakraborty, Hirva Joshi, Rupesh Raina   +3 more
openaire   +2 more sources

Neutrophil‐Mediated Nanozyme Delivery System for Acute Kidney Injury Therapy

Advanced Healthcare Materials
Reactive oxygen species (ROS) scavenging of nanozymes toward acute kidney injury (AKI) is a current promising strategy, however, the glomerular filtration barrier (GFB) limits their application for treating kidney related diseases.
Yu Yang, Jiang Du, Jingjing Gan, Xiang Song, Jiaxin Shu, Chaoli An, Li Lu, Hui Wei, Junyi Che, Xiaozhi Zhao   +9 more
semanticscholar   +1 more source

MEDICAL THERAPY OF ACUTE KIDNEY INJURY

Acta Clinica Belgica, 2007
Pharmacologic interventions for the prevention and therapy of acute kidney injury (AKI) can be roughly divided into 2 main strategies: Optimising renal perfusion and modulation of intrarenal pathophysiological mechanisms, i.e. formation of free oxygen radicals, inflammation, tubular cast formation and renal (tubular) regeneration.
openaire   +2 more sources

WOx Nanosheets Enhance Acute Kidney Injury Therapy Through Geometry‐Improved Targeting and Antioxidant Properties

Aggregate
Ultra‐small nanoparticles, nanowires, and two‐dimensional nanosheets have attracted much attention in acute kidney injury (AKI) treatment. However, the influence of nanostructure geometry on AKI therapy remains unknown.
Yi Wang, Yueping Li, Mengyu Li, Keyi Tang, Shufeng Zhou, Jie Sun, Ruru Zhang, Chanyuan Liu, Yan Liu, Chunyi Liu, Ruixue Duan, Xuewen He   +11 more
semanticscholar   +1 more source

Bubble Sweeping Nanomotors for Acute Kidney Injury Therapy.

ACS Applied Bio Materials
Acute kidney injury (AKI) causes renal ischemic injury and severe damage to the ultrastructure, metabolism, function, and electrophysiology of renal tissue.
Jiahui Sun, Weixin Wang, Rui Gao, Lingyan Qiao, Yini Wang, Fei Tong   +5 more
semanticscholar   +1 more source

Non-Coding RNAs as Targets of Acute Kidney Injury Therapy: Ready for Primetime?

Kidney360
AKI is a common clinical syndrome characterized by its complex pathophysiology and lack of effective therapeutic options, resulting in significantly increased mortality rates and a higher risk of progression to chronic kidney disease.
Zhiwen Liu, Ying Fu, Juan Cai, Guochun Chen, Zheng Dong   +4 more
semanticscholar   +1 more source

Anticoagulation in patients with acute kidney injury undergoing kidney replacement therapy

Pediatric Nephrology, 2021
Kidney replacement therapy (KRT) is used to provide supportive therapy for critically ill patients with severe acute kidney injury and various other non-renal indications. Modalities of KRT include continuous KRT (CKRT), intermittent hemodialysis (HD), and sustained low efficiency daily dialysis (SLED). However, circuit clotting is a major complication
Rupesh Raina, Ronith Chakraborty, Andrew Davenport, Patrick Brophy, Sidharth Sethi, Mignon McCulloch, Timothy Bunchman, Hui Kim Yap   +7 more
openaire   +2 more sources

Fluid Overload Associates With Major Adverse Kidney Events in Critically Ill Patients With Acute Kidney Injury Requiring Continuous Renal Replacement Therapy.

Critical Care Medicine, 2019
OBJECTIVES We examined the association between fluid overload and major adverse kidney events in critically ill patients requiring continuous renal replacement therapy for acute kidney injury. DESIGN Retrospective cohort study.
Connor Woodward, J. Lambert, Victor Ortiz-Soriano, Ye Li, Marice Ruiz-Conejo, B. Bissell, A. Kelly, P. Adams, L. Yessayan, P. Morris, Javier A. Neyra   +10 more
semanticscholar   +1 more source