Results 31 to 40 of about 359,319 (260)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Circulating microRNAs Reveal Time Course of Organ Injury in a Porcine Model of Acetaminophen-Induced Acute Liver Failure [PDF]

, 2015
Acute liver failure is a rare but catastrophic condition which can progress rapidly to multi-organ failure. Studies investigating the onset of individual organ injury such as the liver, kidneys and brain during the evolution of acute liver failure, are ...
A O'Riordan, A Turchinovich, AB Imaeda, AM Larson, AM Reddy, B Ekser, Carolina Palacios Jimenez, CD Williams, CL Andersen, D Mladinov, Diego Calvisi, DJ Antoine, E Cholongitas, F Martino, Fausto Andreola, G Szabo, Hatim Alibhai, HT Zhu, J Hellemans, J Vandesompele, JG O'Grady, JK Moore, K John, K Purins, K Wang, Karla C. L. Lee, KC Lee, Lewis PJ Starkey, Luisa A. Baker, M Karali, M Lagos-Quintana, M Weiland, ML Bajt, MR McGill, MW Pfaffl, N Silver, Nathan A. Davies, O Timoneda, O Timoneda, OF Laterza, P Gilje, P Landgraf, Pamela J. Leckie, PS Mitchell, Q Ge, R Bellomo, Rajeshwar P. Mookerjee, Rajiv Jalan, RL Mehta, RT Stravitz, S Bala, T Kawai, W Bernal, WE Hoffman, WM Lee, X Chen, Y Sun, Y Wang, Y Zhang, Yu-Mei Chang, YW Kong   +60 more
core   +5 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Continued monitoring of acute kidney injury survivors might not be necessary in those regaining an estimated glomerular filtration rate > 60 mL/min at 1 year [PDF]

, 2017
Background. Severe acute kidney injury (AKI) among hospitalized patients often necessitates initiation of short-term dialysis. Little is known about the long-term outcome of those who recover to normal renal function.
Geddes, Colin C., Mark, Patrick B., McQuarrie, Emily P., Stoumpos, Sokratis, Traynor, Jamie P.   +4 more
core   +1 more source

Renal replacement therapy in acute kidney injury – Authors' reply [PDF]

The Lancet, 2020
International ...
Gaudry, Stéphane, Hajage, David, Dechartres, Agnès, Quenot, Jean-Pierre, Dreyfuss, Didier   +4 more
openaire   +3 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Sequential Wnt Agonist then Antagonist Treatment Accelerates Tissue Repair and Minimizes Fibrosis [PDF]

, 2019
Tissue fibrosis compromises organ function and occurs as a potential long-term outcome in response to acute tissue injuries. Currently, lack of mechanistic understanding prevents effective prevention and treatment of the progression from acute injury to ...
Fu, Haiyan, Huang, Sui, Liu, Youhua, Tian, Xiao-Jun, Wang, Xiaojie, Xing, Jianhua, Zhang, Rong, Zhou, Dong   +7 more
core   +2 more sources

Positive effects of a novel non-peptidyl low molecular weight radical scavenger in renal ischemia/reperfusion: a preliminary report [PDF]

, 2014
Ischemia/reperfusion (I/R) is one of the most common causes of acute kidney injury. Reactive oxygen species have been recognized to be an important contributor to the pathogenesis of I/R injury.
A. Mocci, A. Vergani, F. D&apos, J.V. Bonventre, M. Ben Nasr, M.B. Nasr, M.P. Rastaldi, P. Fiorina, R. Bassi, T. Ichimura   +9 more
core   +2 more sources

Predictors of Renal Replacement Therapy in Acute Kidney Injury [PDF]

Nephron Extra, 2012
<b><i>Backgrounds:</i></b> Criteria that may guide early renal replacement therapy (RRT) initiation in patients with acute kidney injury (AKI) currently do not exist. <b><i>Methods:</i></b> In 120 consecutive patients with AKI, clinical and laboratory data were analyzed on admittance. The prognostic power
Koziolek, Michael J., Datta, Rabi R., Mattes, Harry, Jung, Klaus, Heise, Daniel, Streich, Jan H., Mühlhausen, Johannes, Mueller, Gerhard A., Dihazi, Hassan   +8 more
openaire   +3 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source