Results 161 to 170 of about 313,407 (265)

Borylcyclopropanes: Synthetic Strategies and Applications

Angewandte Chemie, EarlyView.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley   +2 more sources

Clinical Outcomes of Adult Patients With Newly Diagnosed Mixed Phenotype Acute Leukemia. [PDF]

JCO Precis Oncol
Goulart H, Ravandi F, Short NJ, Jain N, Daver N, Kadia TM, DiNardo C, Borthakur G, Takahashi K, Pemmaraju N, Haddad FG, Montalban Bravo G, Alvarado Y, Issa GC, Bataller A, Pierce S, Loghavi S, Tang G, Wang SA, Thakral B, Shpall E, Champlin R, Khouri I, Kebriaei P, Garcia-Manero G, Sasaki K, Jabbour EJ, Senapati J.   +27 more
europepmc   +1 more source

Concurrent Germline RB1 & Mosaic TP53 in a Child With Multiple Childhood Cancers

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT We report a patient with a pathogenic germline variant (PGV) in RB1 and somatic mosaicism for a pathogenic TP53 variant who developed three distinct types of childhood cancer: retinoblastoma, osteosarcoma, and myelodysplastic syndrome (MDS) before the age of 6 years.
Ole Haubjerg Nielsen, Ulrik Kristoffer Stoltze, Pernille Axél Gregersen, Marianne Hoffmann, Morten Lyng Høgild, Mette Klarskov Andersen, Lise Barlebo Ahlborn, Lisa Lyngsie Hjalgrim, Karin A. W. Wadt   +8 more
wiley   +1 more source

Erratum to: Genomic breakpoint-specific monitoring of measurable residual disease in pediatric non-standard risk acute myeloid leukemia

Haematologica
Margarita Maurer-Granofszky, Stefan Köhrer, Susanna Fischer, Angela Schumich, Karin Nebral, Patrizia Larghero, Claus Meyer, Astrid Mecklenbräuker, Nora Mühlegger, Rolf Marschalek, Oskar A. Haas, Renate Panzer-Grümayer, Michael N. Dworzak   +12 more
doaj   +1 more source

Case Report: The diagnostic and therapeutic crossroads: when myelofibrosis transforms into mixed phenotype acute leukemia. [PDF]

Front Oncol
Liu Y, Zhang J, Du X, Liao L.
europepmc   +1 more source

From Marginal to Central: Marginal Zone‐like B Cells as Critical Targets in Cladribine‐Treated Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Multiple sclerosis (MS) is a chronic autoimmune disease where B cells play a central pathogenic role. Cladribine, an oral therapy, provides durable benefits by reshaping lymphocyte populations, yet its specific long‐term impact on distinct B‐cell subsets is not fully understood.
Marta Pirronello, Mario Picozza, Gisella Guerrera, Silvia Corbisiero, Andrea Misiti, Roberta C. Placido, Alice Verdiani, Lorenzo de Marco, Manolo Sambucci, Elena Olivieri, Daniela F. Angelini, Esmeralda Quartuccio, Luca Prosperini, Carla Tortorella, Maria C. Buscarinu, Valeria Zancan, Francesca de Masi, Marco Salvetti, Claudio Gasperini, Giovanna Borsellino, Luca Battistini   +20 more
wiley   +1 more source

Digital and Paper-Based Hospital Workflows and 60-Day Mortality in Acute Leukemia: Retrospective Natural Experiment. [PDF]

JMIR Cancer
Ramos Peñafiel CO, Cabrera García Á, Balderas Delgado C, Luna Tentle R, Milán Salvatierra A, Godínez Cubillo N, Acosta Altamirano G, Sánchez Conejo R, Gallardo Rodríguez AG.   +8 more
europepmc   +1 more source

Proinflammatory Epstein–Barr Virus Antibody Functions Track with Disease Activity in Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Epstein–Barr virus (EBV) has been implicated in the pathogenesis of multiple sclerosis (MS). Elevated immunoglobulin G (IgG) titers against EBV nuclear antigen 1 (EBNA1) represent the most consistent serological marker of MS risk, with levels remaining persistently elevated following disease onset.
Malina Behrens, Paula Terroba‐Navajas, Eline A.J. Willemse, Sabine Schädelin, Manuel Comabella, Christian Münz, Gordan Lauc, Yannic Bartsch, Jens Kuhle, Jan D. Lünemann   +9 more
wiley   +1 more source

Nomogram to predict hemorrhage risk related to anti-tumor therapy in patients with acute leukemia. [PDF]

Front Oncol
Hu X, He Y, Xie Y, Zhao L, Wang R, Duan L, Mao P, Han X, Liu Y, Li C.   +9 more
europepmc   +1 more source

Leveraging genomic diagnostics for prognostics and therapeutics in pediatric acute leukemia. [PDF]

Hemasphere
Newman H, Wong D, Wu J, Schubert J, Golenberg N, Naveh N, Patel M, Xu F, Charles S, Chen J, Denenberg EH, Fanning EA, Gallo D, Luke T, Thomas M, Cao K, Chan AJS, Holloman M, Fan Z, Fu W, Hunger SP, MacFarland SP, Bernt KM, Surrey LF, Luo M, Wertheim GB, Li MM, Tasian SK, Zhong Y.   +28 more
europepmc   +1 more source