Results 181 to 190 of about 313,407 (265)

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Pleural Infiltration Revealing Post‐Essential Thrombocythemia Acute Myeloid Leukaemia

eJHaem
Clémentine Muron, Damien Luque Paz, Marie‐Christine Copin, Corentin Orvain   +3 more
doaj   +1 more source

Acute leukemia during pregnancy: a single center experience with 23 cases, 2012-2022 and literature review. [PDF]

Ann Med
Liu W, Guo J, Gai D, Zhang KX, Liu Y, Zhao XL, Fu X, Rosen ST, Chen C, Chen F.   +9 more
europepmc   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

International testing and refinement of AI algorithms predicting acute leukemia subtypes from routine laboratory data. [PDF]

Nat Commun
Turki AT, Fan Y, Hernández-Sánchez A, Silva W, Fleming S, Yalcin K, Van Elssen CHMJ, Madanat Y, Karasek M, Aljurf M, Della Porta MG, Martinez-Roca A, Guarnera L, Steffen K, Antoniou E, Rivas MM, Mishra DK, Blum AT, Manantsoa SN, Adiat A, Enshaei A, Thol F, Voso MT, Chen J, Elhassan TA, Moorman AV, Vidriales MB, Neuendorff NR, Koc A, Mishra P, Strumberg D, Fourmanov RS, Heine L, Kleesiek J, Munárriz D, Asti G, Mokoonlall M, Kometas M, Rego E, Mecklenbrauck R, Sobas M, Wu D, Nensa F, Engelke M.   +43 more
europepmc   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Oral Necrotizing Ulcerations in Acute Leukemia Patients: Clinical Characteristics, Integrated Management, and Favorable Outcomes - A Case Series. [PDF]

Int Med Case Rep J
Priandhika FH, Hidayat W, Fitriasari N.
europepmc   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Detection of Fusion Genes Using RNA Sequencing in Acute Leukemia. [PDF]

Ann Lab Med
Kim HY, Kim B, Park MS, Park JH, Ju HY, Yoo KH, Jang JH, Jung CW, Kim HJ.   +8 more
europepmc   +1 more source

Neurofilament light chain as in vitro and clinical biomarker of vincristine‐induced peripheral neuropathy

British Journal of Clinical Pharmacology, EarlyView.
Aims Vincristine‐induced peripheral neuropathy (VIPN) is a common side effect in children and adolescents treated with vincristine. Assessing VIPN, especially in young children, is challenging due to a lack of sensitive tools. This limits our understanding of the nature and risk factors of VIPN. This study aimed to investigate neurofilament light chain
Peter Erik Lotko Pontoppidan, Christian Bach Vase, Christina Mortensen, Liv Andres‐Jensen, Dorte Aalund Olsen, Jonna Skov Madsen, Kjeld Schmiegelow, Rene Mathiasen, Tore Bjerregaard Stage   +8 more
wiley   +1 more source