Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion
FUT8‐mediated core fucosylation of CD47 at N111 blocks SMURF1 binding and reduces CD47 ubiquitination and degradation. Blocking N111 glycosylation reduces CD47 expression and promotes macrophage phagocytosis of tumor cells. Furthermore, ablating CD47 core fucosylation boosts CD103+ dendritic cells (DCs) infiltration, increases natural killer (NK) cell ...
Yuting Cao +8 more
wiley +1 more source
Construction and validation of a risk prediction model for complications in patients with acute leukemia based on machine learning. [PDF]
Xu R, Tian H, Zhao S, Gu S.
europepmc +1 more source
Up-Regulation of P21 Inhibits TRAIL-Mediated Extrinsic Apoptosis, Contributing Resistance to SAHA in Acute Myeloid Leukemia Cells [PDF]
Xing Wu +11 more
openalex +1 more source
Plasma levels of Human Granulocytic Elastase-alpha-Proteinase Inhibitor Complex (E-alpha1PI) in Leukemia [PDF]
Hiller, E., Jochum, Marianne
core
This study presents an ultrasound‐responsive hydrogel (MCF@CA) that co‐delivers a neuropeptide (CGRP) and a ROS‐scavenging manganese porphyrin to diabetic wounds. The system restores neuro‐immune communication, reprograms macrophages toward an anti‐inflammatory phenotype, and clears excess ROS, thereby accelerating wound closure and promoting mature ...
Mofan Li +9 more
wiley +1 more source
This study presents sulfate‐directed silver dendrites (s‐AgDs) as oxidation‐resistant SERS substrates with long‐term stability, reproducibility, and sub‐picomolar sensitivity. Sulfate ions guide anisotropic growth and protect the surface, enabling improved performance over 7 months under ambient conditions.
Aradhana Dwivedi +6 more
wiley +1 more source
Prophylactic donor lymphocyte infusions after first allogeneic hematopoietic stem cell transplantation in children with acute leukemia. [PDF]
Wei A +14 more
europepmc +1 more source
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Analyses of transplantation outcomes for adult patients with mixed-phenotype acute leukemia. [PDF]
Jo T +19 more
europepmc +1 more source
Seasonality of birth and acute lymphoblastic leukemia [PDF]
Kajtár, Pál +2 more
core +1 more source

