Results 211 to 220 of about 3,808,290 (359)

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source

Acute leukemia of ambiguous lineage: the known and the uncertain. [PDF]

Haematologica
Sherban A, Wolach O.
europepmc   +1 more source

Acute Megakaryocytic Leukemia [PDF]

Mayo Clinic Proceedings, 1989
openaire   +2 more sources

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Nomogram to predict hemorrhage risk related to anti-tumor therapy in patients with acute leukemia. [PDF]

Front Oncol
Hu X, He Y, Xie Y, Zhao L, Wang R, Duan L, Mao P, Han X, Liu Y, Li C.   +9 more
europepmc   +1 more source

SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics

Advanced Science, EarlyView.
ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao, Gaiqin Liu, Jingyi Xia, Runle Chen, Tong Wang, Xiaoling Yang, Ruiling Fang, Yanhong Luo, Ping Zeng, Hongmei Yu, Yanbo Zhang, Yuehua Cui   +11 more
wiley   +1 more source

Clinical Outcomes of Adult Patients With Newly Diagnosed Mixed Phenotype Acute Leukemia. [PDF]

JCO Precis Oncol
Goulart H, Ravandi F, Short NJ, Jain N, Daver N, Kadia TM, DiNardo C, Borthakur G, Takahashi K, Pemmaraju N, Haddad FG, Montalban Bravo G, Alvarado Y, Issa GC, Bataller A, Pierce S, Loghavi S, Tang G, Wang SA, Thakral B, Shpall E, Champlin R, Khouri I, Kebriaei P, Garcia-Manero G, Sasaki K, Jabbour EJ, Senapati J.   +27 more
europepmc   +1 more source

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

Nature Medicine, 2018
D. Pollyea, Brett M. Stevens, Courtney L Jones, Amanda C. Winters, Shanshan Pei, Mohammad Minhajuddin, A. D’Alessandro, Rachel Culp-Hill, K. Riemondy, A. Gillen, J. Hesselberth, Diana Abbott, Derek Schatz, J. Gutman, E. Purev, Clayton A. Smith, C. Jordan   +16 more
semanticscholar   +1 more source

Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression

Advanced Science, EarlyView.
This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng, Shuang Cai, Chen Guo, Shaker Khan, Lefan Liu, Qiong Tian, Zhiyuan Ma, Jian Zhang, Lingyu Zhao   +8 more
wiley   +1 more source

Leveraging genomic diagnostics for prognostics and therapeutics in pediatric acute leukemia. [PDF]

Hemasphere
Newman H, Wong D, Wu J, Schubert J, Golenberg N, Naveh N, Patel M, Xu F, Charles S, Chen J, Denenberg EH, Fanning EA, Gallo D, Luke T, Thomas M, Cao K, Chan AJS, Holloman M, Fan Z, Fu W, Hunger SP, MacFarland SP, Bernt KM, Surrey LF, Luo M, Wertheim GB, Li MM, Tasian SK, Zhong Y.   +28 more
europepmc   +1 more source