Results 221 to 230 of about 3,808,290 (359)

CD28‐Targeted Enzyme‐Responsive Conformation‐Switching Peptide Self‐Assembly for Selective T‐Cell Acute Lymphoblastic Leukemia (T‐ALL) Therapy

Advanced Science, EarlyView.
We developed the enzyme‐responsive peptide SAp‐CD28 to selectively target CD28‐overexpressing T‐ALL cells. Following phosphatase‐mediated activation, SAp‐CD28 undergoes conformational switching and nanooligomerization, resulting in the disruption of CD28 downstream signaling.
Jun Li, Ziyu Jia, Dekun Li, Zhi‐Wen Hu, Yinghao Ding, Shengyi Zhang, Shengkun Tuo, Zhimou Yang, Huisheng Fu, Ling Wang, Man‐Di Wang   +10 more
wiley   +1 more source

CD9, a tetraspanin in cancer: biology and therapeutic promise in acute leukemia. [PDF]

Oncogenesis
Guého O, Cousin E, Rouger-Gaudichon J, Rio AG, Corre S, Gandemer V, Mazurier F.   +6 more
europepmc   +1 more source

Molecular Minimal Residual Disease in Acute Myeloid Leukemia

New England Journal of Medicine, 2018
M. Jongen‐Lavrencic, T. Grob, Diana Hanekamp, F. Kavelaars, A. A. Al Hinai, A. Zeilemaker, Claudia A. J. Erpelinck-Verschueren, P. Gradowska, R. Meijer, J. Cloos, B. Biemond, C. Graux, M. van Marwijk Kooy, M. Manz, T. Pabst, J. Passweg, V. Havelange, G. Ossenkoppele, M. Sanders, G. Schuurhuis, B. Löwenberg, P. Valk   +21 more
semanticscholar   +1 more source

Dual‐Targeting Cuproptosis and Mitophagy via a Flavopiridol‐Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma

Advanced Science, EarlyView.
This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren, Zhihong Deng, Sheng Lu, Jing Zhang, Wenbin Liu, Jia Tan   +5 more
wiley   +1 more source

Acute leukemia during pregnancy: a single center experience with 23 cases, 2012-2022 and literature review. [PDF]

Ann Med
Liu W, Guo J, Gai D, Zhang KX, Liu Y, Zhao XL, Fu X, Rosen ST, Chen C, Chen F.   +9 more
europepmc   +1 more source

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

International testing and refinement of AI algorithms predicting acute leukemia subtypes from routine laboratory data. [PDF]

Nat Commun
Turki AT, Fan Y, Hernández-Sánchez A, Silva W, Fleming S, Yalcin K, Van Elssen CHMJ, Madanat Y, Karasek M, Aljurf M, Della Porta MG, Martinez-Roca A, Guarnera L, Steffen K, Antoniou E, Rivas MM, Mishra DK, Blum AT, Manantsoa SN, Adiat A, Enshaei A, Thol F, Voso MT, Chen J, Elhassan TA, Moorman AV, Vidriales MB, Neuendorff NR, Koc A, Mishra P, Strumberg D, Fourmanov RS, Heine L, Kleesiek J, Munárriz D, Asti G, Mokoonlall M, Kometas M, Rego E, Mecklenbrauck R, Sobas M, Wu D, Nensa F, Engelke M.   +43 more
europepmc   +1 more source

Somatic mutations precede acute myeloid leukemia years before diagnosis

Nature Medicine, 2018
Pinkal M. Desai, N. Mencia-Trinchant, O. Savenkov, M. Simon, Gloria Cheang, Sangmin Lee, Michael B. Samuel, E. Ritchie, M. Guzman, K. Ballman, G. Roboz, D. Hassane   +11 more
semanticscholar   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Oral Necrotizing Ulcerations in Acute Leukemia Patients: Clinical Characteristics, Integrated Management, and Favorable Outcomes - A Case Series. [PDF]

Int Med Case Rep J
Priandhika FH, Hidayat W, Fitriasari N.
europepmc   +1 more source