Results 251 to 260 of about 3,808,290 (359)

PAIR: Reconstructing Single‐Cell Open‐Chromatin Landscapes for Transcription Factor Regulome Mapping

Advanced Science, EarlyView.
scATAC‐seq analysis is often constrained by limited sequencing depth, extreme sparsity, and pervasive technical missingness. PAIR is a probabilistic framework that restores scATAC‐seq accessibility profiles by directly modeling the native cell–peak bipartite structure of chromatin accessibility.
Yanchi Su, Qi Qi, Yi Fan, Yubo Wang, Gaoyang Hao, Ka‐Chun Wong, Yunhe Wang, Xiangtao Li   +7 more
wiley   +1 more source

Feasibility of an oral hydration regimen post high-dose methotrexate in children with acute leukemia: a pilot study. [PDF]

Discov Oncol
Karri PS, Sidhique Pr R, Meena JP, Seth R, Gupta AK.   +4 more
europepmc   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Leveraging the heterogeneity of the NK cell repertoire for the development of immunotherapies for acute leukemia. [PDF]

J Transl Med
Ferron E, Jullien M, Gagne K, Retière C.   +3 more
europepmc   +1 more source

A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias [PDF]

, 2005
Benoit, Yves, BILLIET, J, BOOGAERTS, M, Cauwelier, Barbara, COOLS, J, DASTUGUE, N, De Moerloose, Barbara, De Paepe, Anne, GRAUX, C, HAGEMEIJER, A, HUGUET, F, MARYNEN, P, Poppe, Bruce, ROBERT, A, SELLESLAG, D, Speleman, Franki, UYTTEBROECK, A, Van Roy, Nadine, VANDENBERGHE, P, Vandesompele, Jo, Verhasselt, Bruno   +20 more
core  

Trained Memory of Uterine Macrophages Improves Subsequent Pregnancy Outcomes

Advanced Science, EarlyView.
This study identifies that pregnancy imprints a durable, pregnancy‐specific form of trained immune memory in uterine macrophages, marked by the emergence of LILRB3+/PIR‐B+ cells that expand across gestations, acquire a tolerogenic and metabolically rewired phenotype, and actively protect against inflammatory pregnancy loss in mice.
Jing Wang, Ning Lu, Xin‐Xiu Lin, Xu‐Hui Fang, Yi‐Hui Li, Qing‐Peng Luo, Yu‐Ting Peng, Gil Mor, Ai‐Hua Liao   +8 more
wiley   +1 more source

DNA Damage Sensing and TP53 Function as Modulators of Sensitivity to Calicheamicin-Based Antibody-Drug Conjugates for Acute Leukemia. [PDF]

Cancers (Basel)
Pettenger-Willey CM, Laszlo GS, Gang M, Cole FM, Godwin CD, Erraiss S, Chanana P, Kehret AR, Li J, Barton JW, Yochim MM, Rodríguez-Arbolí E, Walter RB.   +12 more
europepmc   +1 more source

SDS‐CRISPR for Single‐Nucleotide Variant Detection

Advanced Science, EarlyView.
Structure‐disruption‐sensitive CRISPR (SDS‐CRISPR) converts structural instability into single‐nucleotide precision, thereby overcoming mismatch tolerance in canonical Cas12a and enabling versatile diagnostics across DNA, RNA, and microRNA targets. When applied to rapid IDH1 mutation detection for glioma genotyping and integrated with lateral‐flow ...
Xin Guan, Chong Guo, Jiongyu Zhang, Rui Yang, Yerramsetti Ramachandra, Chengyu Hou, Minjie Pei, Shuo Zhang, Kurt T. Schalper, Xingye Liu, Qian Wu, Ketan R. Bulsara, Changchun Liu   +12 more
wiley   +1 more source

Geographic and Socioeconomic Determinants of Treatment Abandonment in Pediatric Acute Leukemia: A Cohort Study in South-Central Mexico. [PDF]

Cancer Control
Núñez-Enriquez JC, Luna-Silva NC, Jacuinde-Trejo K, Flores-Lujano J, Medina-León D, Alarcón-Ruiz E, Garrido-Hernández MÁ, Cruz-Medina CS, Tinoco-Montejano D, Baños-Lara MDR, Campo-Martínez MLÁD, Duarte-Rodríguez DA, Allende-López A, Casique-Aguirre D, Elizarrarás-Rivas J, Olvera-Caraza D, Solís-Poblano JC, Terán-Cerqueda V, Ramírez-Ramírez D, Huerta-Moreno A, Aristil-Chery PM, Romo-Rodríguez R, Alvarez-Rodríguez E, Lien-Chang LEJ, Zamora-Herrera G, Hidalgo BG, Herrera-Olivares W, Ruíz-Arguelles GJ, Gallardo-Pérez MM, Chávez-Aguilar LA, Márquez-Toledo A, Cano-Cuapio LS, Ramos RH, Martínez-Martell MA, Ramirez-Ramirez AB, Brindis NR, Montiel-Jarquín AJ, Galván-Díaz CA, Velasco-Hidalgo L, Medina-Sanson A, Gutiérrez-Rivera ML, Cárdenas-Conejo A, Morales-Maravilla A, Victorio-García NP, Bekker-Méndez VC, Romero-Tlalolini MLÁ, Rodríguez-Espinosa JC, Mata-Rocha M, Olivares-Sosa AI, Rosas-Vargas H, Jiménez-Morales S, Martínez MEJ, Cárdenas-González M, Mejía-Aranguré JM, López-Aguilar E, Zapata-Tarrés M, Pelayo R.   +56 more
europepmc   +1 more source