Results 261 to 270 of about 3,808,290 (359)

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

Pleural Infiltration Revealing Post‐Essential Thrombocythemia Acute Myeloid Leukaemia

eJHaem
Clémentine Muron, Damien Luque Paz, Marie‐Christine Copin, Corentin Orvain   +3 more
doaj   +1 more source

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine

Advanced Science, EarlyView.
Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O. Larkotey, Yang Li, Yinghui Shi, Wenya Shu, Lin Wang, Weiqing Wang, Tian Jian Lu, Yulong Han   +15 more
wiley   +1 more source

Semen quality in acute leukemia patients: a retrospective study. [PDF]

Ann Hematol
Buonacquisto A, Del Principe MI, Pallotti F, Bianchini S, Buzzatti E, Caponecchia L, Chiaretti S, Cicolani G, Conflitti AC, Di Chiano S, Fucci L, Kasmi D, Minotti C, Paterno G, Tiravanti I, Venditti A, Lombardo F, Paoli D.   +17 more
europepmc   +1 more source

Genetic Code Expanded T Cell for Controllable Immunotherapy

Advanced Science, EarlyView.
Our GCE‐CAR‐T cells enables tight, dose‐dependent, and function‐preserving control of CAR expression at the translational level through amber codon suppression and genetic incorporation of ncAA. ABSTRACT Chimeric antigen receptor (CAR)‐T cell therapy has demonstrated curative potential against hematologic malignancies, but its clinical application ...
Xue Wang, Yingao Gao, Yeyu Su, Yong Wang, Tao Liu   +4 more
wiley   +1 more source

The sobering reality of fertility preservation in young female patients with acute leukemia. [PDF]

Haematologica
Frisch A.
europepmc   +1 more source

Technoeconomic and sustainability analysis of batch and continuous crystallization for pharmaceutical manufacturing

AIChE Journal, EarlyView.
Abstract In pharmaceutical industries, continuous manufacturing methods have already been well established to improve productivity and process intensification. However, to better understand the trade‐offs of continuous crystallizers over the existing batch production systems, a robust technoeconomic cost and sustainability analysis is necessary to ...
Jungsoo Rhim, Zoltan K. Nagy
wiley   +1 more source

Prevalence and risk factors of metabolic syndrome in survivors of childhood acute leukemia: a systematic review and meta-analysis. [PDF]

Diabetol Metab Syndr
Wei Z, Du Z, Liu H, Zheng J, Lu Q, Hu S.
europepmc   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

The genomic landscape of relapsed infant and childhood KMT2A-rearranged acute leukemia. [PDF]

Nat Commun
Ahlgren L, Pilheden M, Sturesson H, Song G, Walsh MP, Yang M, Maillard M, Zhao H, Cheng Z, Singh V, Castor A, Pronk CJ, Marquart HV, Lausen B, Schneider P, Barbany G, Pokrovskaja Tamm K, Abrahamsson J, Lohi O, Fogelstrand L, Menendez P, Pieters R, Zhang J, Lindkvist-Petersson K, Yang JJ, Gruber TA, Stam RW, Ma J, Hagström-Andersson AK.   +28 more
europepmc   +1 more source