Histone deacetylase inhibitors: targeting epigenetic regulation in the treatment of acute leukemia. [PDF]
Xiao T+5 more
europepmc +1 more source
Objective Two randomized trials for patients with diffuse systemic sclerosis (SSc) demonstrated an overall survival (OS) and event‐free survival (EFS) advantage of autologous hematopoietic stem cell transplantation (AHSCT) using CD34+ selected peripheral blood stem cells (PBSCs) compared with monthly cyclophosphamide (CY).
George E. Georges+16 more
wiley +1 more source
Acute leukemia with KMT2A rearrangement: A master of disguise. [PDF]
Bawek SJ, Wang ES, Green SD.
europepmc +1 more source
Objective An unmet need exists for glucocorticoid‐sparing treatments for patients with polymyalgia rheumatica (PMR). The antibody‐drug conjugate ABBV‐154 comprises adalimumab conjugated to a glucocorticoid receptor modulator. We evaluated ABBV‐154 versus placebo in patients with glucocorticoid‐dependent PMR.
Robert F. Spiera+14 more
wiley +1 more source
Clostridium perfringens Sepsis Complicated by Hepatic Abscess Following Intensive Chemotherapy in Mixed-Phenotype Acute Leukemia. [PDF]
Baptista P+4 more
europepmc +1 more source
Severe myelosuppression and alopecia after thiopurine initiation in a patient with NUDT15 deficiency
Thiopurines are a class of immunosuppressant and antineoplastic agents. They are widely used in the treatment of inflammatory bowel disease, haematological malignancies and autoimmune diseases, but can cause significant toxicity. Inherited gene mutations are now recognized as independent risk factors for severe adverse drug reactions to thiopurines ...
Annie Siyu Wu+3 more
wiley +1 more source
Recent Developments and Challenges in the Treatment of Acute Leukemia and Myelodysplastic Syndromes: A Systematic Review. [PDF]
Rafiq N+11 more
europepmc +1 more source
Resilience Development Among Adult Patients With De Novo Acute Leukemia: A Qualitative Study. [PDF]
Li D, Li J, He X, Zhang M.
europepmc +1 more source
Is Enhancer Function Driven by Protein–Protein Interactions? From Bacteria to Leukemia
Enhancers are key regulatory elements that are conceptually conserved from bacteria to humans. Enhancer dysregulation is common in cancers, including leukemia. We argue that highly specific protein–protein interactions, including transcription factors, mediate enhancer‐promoter proximity to allow enhancer‐bound factors to directly act on RNA polymerase
Nicholas T. Crump, Thomas A. Milne
wiley +1 more source
Current insights on m6A RNA modification in acute leukemia: therapeutic targets and future prospects. [PDF]
Kaur P, Sharma P, Bhatia P, Singh M.
europepmc +1 more source