Results 171 to 180 of about 1,991,339 (283)

Cannula Pairing Determines Distal Limb Perfusion During Peripheral Veno‐Arterial Extracorporeal Membrane Oxygenation: An Experimental Mock‐Loop Study

Artificial Organs, EarlyView.
Introducer sheaths are commonly used as distal perfusion cannulas during VA‐ECMO; efficacy is uncertain. A simplified hydraulic bench experiment evaluated cannula and connection configurations during clinically relevant blood flow using water and simulated blood media. Distal flow fraction decreased with larger arterial cannulas and was not restored by
Elliott Worku, Richard Lee, Ruaidhri Carey, Andre Kyme, Timothy Southwood   +4 more
wiley   +1 more source

Uncovering the Unexpected-True Lumen Compression by Subintimal Stent Causing Recurrent Acute Limb Ischemia for 15 Years: A Case Report. [PDF]

J Soc Cardiovasc Angiogr Interv
Wong G, Teixeira PS, Sheikh O, Shishehbor MH.   +3 more
europepmc   +1 more source

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α‐synuclein preformed fibrils‐induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

Brain Pathology, EarlyView.
Omics‐driven drug repositioning reveals pyroxamide as a neuroprotective HDAC1 inhibitor in Parkinson's disease models. Abstract Parkinson's disease (PD) is the second most common neurodegenerative disorder mainly characterized by the degeneration of dopaminergic neurons originating in the substantia nigra (SN) pars compacta and projecting to other ...
Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana, Mercedes Lachén‐Montes, Silvia Romero‐Murillo, Djordje Gveric, Joaquín Fernández‐Irigoyen, Enrique Santamaría   +7 more
wiley   +1 more source

Staged hybrid repair under local anesthesia for ruptured iliac artery aneurysm with iliocaval fistula and acute limb ischemia in a frail patient. [PDF]

J Vasc Surg Cases Innov Tech
Chu WG.
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Hybrid Surgical Approach for Acute Limb Ischemia: A Case Report and Management Algorithm. [PDF]

Cureus
Antonopoulos CN, Pitros CF, Panagiotopoulos A, Lazaris AM.   +3 more
europepmc   +1 more source

Highly potent, brain‐penetrant EP2 receptor antagonists for the treatment of permanent focal cerebral ischaemia in male and female mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Cerebral ischaemia is a leading cause of death in older adults and imposes a substantial global economic burden. Recent studies indicate that inhibiting the Gαs‐coupled EP2 receptor reduces ischaemic brain injury by modulating neuroinflammation.
Zhen Jin, Chenyao Jiang, Eun Bee Cho, M. Dennis Leo, Jiukuan Hao, Jiawang Liu, Ying Yu, Jianxiong Jiang   +7 more
wiley   +1 more source

Bilateral Persistent Sciatic Artery With Unilateral Thrombosis: A Rare Case of Acute Limb Ischemia Successfully Managed With Endovascular Intervention. [PDF]

Catheter Cardiovasc Interv
Abdul-Hafez HA, Zayed A, Abbas K, Barakat MA, Abuzahra MA, Hamdan L.   +5 more
europepmc   +1 more source

Targeting a Novel AREG+ Dendritic Cell Alleviates Renal Fibrosis Induced by Ischemia–Reperfusion Injury

Cell Proliferation, EarlyView.
Renal IRI induces tubular EMT and fibrosis. CD11c+AREG+ DCs mediate the process via AREG‐EGFR axis, serving as promising therapeutic targets. ABSTRACT Renal ischemia–reperfusion injury (RIRI) is a major cause of acute tubular damage and a key driver of maladaptive repair and fibrosis.
Xin Luo, Longbin Xiong, Zhaohui Zhou, Lihao Zhang, Yulu Peng, Xiangpeng Zou, Yixin Huang, Yisong Lin, Xiaofeng Yang, Zhanji Zhan, Fangjian Zhou, Youhua Liu, Chunping Yu, Baokui Ye, Zhiling Zhang   +14 more
wiley   +1 more source

Recurrent Acute Limb Ischemia and Direct Oral Anticoagulant Failure: A Case of Suspected Antiphospholipid Syndrome Triggered by Mechanical Compression. [PDF]

Cureus
Almaradweh S, Manikkavelu MK, Oye H.
europepmc   +1 more source