Results 71 to 80 of about 1,991,339 (283)

Dynamics of endogenous intoxication indicators in condition of acute blood loss complicated by ischemia-reperfusion of the limb, and their correction by carbacetam

Journal of Education, Health and Sport, 2020
Introduction. In the structure of injuries from gunshot wounds dominate the limb injuries that are often complicated by massive bleeding from the main vessels. The only means of rescue on the battlefield is a timely application of a tourniquet.
I. Strelbytska, A. Hudyma
doaj   +1 more source

Rare presentation of Waldenström’s macroglobulinaemia requiring bilateral above-knee amputations: a case report

Journal of Medical Case Reports, 2022
Background Waldenström’s macroglobulinaemia is a rarely encountered B-lymphocytic malignancy. Waldenström’s macroglobulinaemia-associated paraproteinaemia is linked to an increase in serum viscosity, which results in a hypercoagulable state.
Raeed Deen, Calyb Austin, Alexander Bowden, Andrew Bullen   +3 more
doaj   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Does the new vascular management of acute limb ischemia have effective results with lower treatment costs [PDF]

Medicinski Glasnik, 2019
Aim To compare hospital costs of acute limb ischemia treatment in two periods of time and to show evidence of long-term repercussions on reducing costs during successful treatment.
Haris Vukas, Samra Kadić-Vukas, Senad Dervišević, Adis Salihbegović, Haris Vranić, Muhamed Djedović, Amel Hadžimehmedagić, Dragan Totić   +7 more
doaj   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

A Case of Needle-Directed Pulse-Spray Pharmacomechanical Thrombolysis of Acute Brachial Artery Thrombosis

Journal of Clinical Interventional Radiology ISVIR, 2019
Acute limb ischemia is a serious disabling condition. The management options depend upon the patient symptoms and signs of ischemia in the affected limb.
Yugandhar Samireddypalle, Uma Maheshwara Reddy V., Chinmay Deepak, Sankar Neelakantan, Amitha Vikrama KS   +4 more
doaj   +1 more source

Management of acute limb ischemia in the pediatric population [PDF]

Journal of Vascular Surgery, 2013
Acute limb ischemia (ALI) in pediatric patients is rare but may lead to limb loss and life-long complications. This study reviewed the experience of a Canadian tertiary pediatric center with the medical and operative management of ALI.The medical records of inpatients diagnosed with ALI of the upper or lower limb between 1999 and 2012 were reviewed ...
Kayssi, Ahmed, Shaikh, Furqan, Roche-Nagle, Graham, Rubin, Barry, Brandao, Leonardo R., Williams, Suzan A.   +5 more
openaire   +3 more sources

Self‐Adaptive Biomimetic Nanocomposite Hydrogel Orchestrates Dual‐Targeting and On‐Demand H2S Gasotransmission for Multifactorial Diabetic Wound Therapy

Advanced Science, EarlyView.
A self‐adaptive and biomimetic nanocomposite hydrogel is engineered to orchestrate dual‐targeting and on‐demand H2S gasotransmission for multifactorial diabetic wound therapy. By seamlessly integrating antibacterial, antioxidant, anti‐inflammatory, immunoregulatory, and pro‐angiogenic functions within a single platform, this hydrogel dynamically ...
Kefan Wu, Xiaoxue Yang, Yonghang Liu, Yi Xiao, Shiyu Meng, Ao Li, Yi Zhun Zhu, Hui Guo, Xiaolin Wang   +8 more
wiley   +1 more source

SURGICAL MANAGEMENT OF ACUTE EMBOLIC LIMB ISCHEMIA - AN EXPERIENCE OF 256 CASES

Journal of University Medical & Dental College, 2015
OBJECTIVES: To highlight the importance of embolectomy in patients with acute embolic limb ischemia. STUDY DESIGN: Descriptive analytic study. PLACE AND DURATION OF STUDY: The Department of Vascular Surgery, Combined Military Hospital Lahore, from July ...
Muhammad Jamil , Rashid Usman
doaj  

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source